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UniProt functional annotation for Q9FBI2 | ||
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| UniProt code: Q9FBI2. |
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| Organism: | |
Shigella dysenteriae. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella. |
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| Function: | |
The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits. |
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| Catalytic activity: | |
Reaction=Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.; EC=3.2.2.22; |
| Subunit: | |
Shiga toxin contains a single subunit A and five copies of subunit B. |
| Similarity: | |
Belongs to the ribosome-inactivating protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.