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UniProt functional annotation for Q7BQ98 | ||
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| UniProt code: Q7BQ98. |
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| Organism: | |
Shigella dysenteriae. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella. |
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| Function: | |
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli. {ECO:0000269|PubMed:2677606}. |
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| Subunit: | |
Shiga toxin contains a single subunit A and five copies of subunit B. |
| Induction: | |
Maximal induction occurs at 37 degrees Celsius and in low- iron environments. {ECO:0000269|PubMed:6360895}. |
| Domain: | |
There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3. |
| Similarity: | |
Belongs to the StxB family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.