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UniProt functional annotation for Q07009 | ||
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| UniProt code: Q07009. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. {ECO:0000250|UniProtKB:O08529, ECO:0000250|UniProtKB:P17655}. |
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| Catalytic activity: | |
Reaction=Broad endopeptidase specificity.; EC=3.4.22.53; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 7 Ca(2+) ions.; |
| Activity regulation: | |
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. |
| Subunit: | |
Forms a heterodimer with a small (regulatory) subunit (CAPNS1) (PubMed:19020622, PubMed:19020623). Interacts with CPEB3; this leads to cleavage of CPEB3 (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:19020622, ECO:0000269|PubMed:19020623}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}. |
| Tissue specificity: | |
Ubiquitous. |
| Similarity: | |
Belongs to the peptidase C2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.