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PDBsum entry 1dab
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Cell adhesion PDB id
1dab

 

 

 

 

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Contents
Protein chain
539 a.a. *
Waters ×277
* Residue conservation analysis
PDB id:
1dab
Name: Cell adhesion
Title: The structure of bordetella pertussis virulence factor p.69 pertactin
Structure: P.69 pertactin. Chain: a. Engineered: yes
Source: Bordetella pertussis. Organism_taxid: 520. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Hexamer (from PQS)
Resolution:
2.50Å     R-factor:   0.250     R-free:   0.276
Authors: P.Emsley,I.G.Charles,N.F.Fairweather,N.W.Isaacs
Key ref: P.Emsley et al. (1996). Structure of Bordetella pertussis virulence factor P.69 pertactin. Nature, 381, 90-92. PubMed id: 8609998
Date:
31-Oct-99     Release date:   15-Dec-99    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P14283  (PERT_BORPE) -  Pertactin autotransporter from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Seq:
Struc: 		 
Seq:
Struc: 		910 a.a.
539 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Nature 381:90-92 (1996)
PubMed id: 8609998  
 
 
Structure of Bordetella pertussis virulence factor P.69 pertactin.
P.Emsley, I.G.Charles, N.F.Fairweather, N.W.Isaacs.
 
  ABSTRACT  
 
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence. The X-ray crystal structure of P.69 pertactin has been determined to 2.5 A. The protein fold consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is the largest beta-helix known to date. Several between-strand weakly conserved amino-acid repeats form internal and external ladders. The structure appears as a helix from which several loops protrude, which contain sequence motifs associated with the biological activity of the protein. One particular (GGXXP)5 sequence is located directly after the RGD motif, and may mediate interaction with epithelial cells. The carboxy-terminal region of P.69 pertactin incorporates a (PQP)5 motif loop containing the major immunoprotective epitope.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
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PDB code: 3qq2
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Immunodominance in mouse and human CD4+ T-cell responses specific for the Bordetella pertussis virulence factor P.69 pertactin.
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18972542 D.O.Serra, G.Lücking, F.Weiland, S.Schulz, A.Görg, O.M.Yantorno, and M.Ehling-Schulz (2008).
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PDB code: 2iou
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PDB code: 2qom
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PDB codes: 2f3l 2g0y
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17041044 M.E.Charbonneau, F.Berthiaume, and M.Mourez (2006).
Proteolytic processing is not essential for multiple functions of the Escherichia coli autotransporter adhesin involved in diffuse adherence (AIDA-I).
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Surface display of proteins by gram-negative bacterial autotransporters.
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Protein secretion and secreted proteins in pathogenic Neisseriaceae.
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Solid-state NMR as a probe of amyloid structure.
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Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli.
  J Biol Chem, 280, 17339-17345.
PDB code: 1wxr
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Bordetella bronchiseptica adherence to cilia is mediated by multiple adhesin factors and blocked by surfactant protein A.
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15837807 N.R.Thomson, C.Yeats, K.Bell, M.T.Holden, S.D.Bentley, M.Livingstone, A.M.Cerdeño-Tárraga, B.Harris, J.Doggett, D.Ormond, K.Mungall, K.Clarke, T.Feltwell, Z.Hance, M.Sanders, M.A.Quail, C.Price, B.G.Barrell, J.Parkhill, and D.Longbottom (2005).
The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation.
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Epimerase active domain of Pseudomonas aeruginosa AlgG, a protein that contains a right-handed beta-helix.
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The C-type lectin fold as an evolutionary solution for massive sequence variation.
  Nat Struct Mol Biol, 12, 886-892.
PDB codes: 1yu0 1yu1 1yu2 1yu3 1yu4
15831828 S.Mattoo, and J.D.Cherry (2005).
Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.
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A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structure.
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The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway.
  Proc Natl Acad Sci U S A, 101, 6194-6199.
PDB code: 1rwr
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Structure of the translocator domain of a bacterial autotransporter.
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PDB codes: 1uyn 1uyo
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Type V protein secretion pathway: the autotransporter story.
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PDB codes: 1ogm 1ogo
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PDB code: 1h80
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PDB code: 1ee6
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1.68-A crystal structure of endopolygalacturonase II from Aspergillus niger and identification of active site residues by site-directed mutagenesis.
  J Biol Chem, 274, 30474-30480.
PDB code: 1czf
  9655353 A.Bateman, A.G.Murzin, and S.A.Teichmann (1998).
Structure and distribution of pentapeptide repeats in bacteria.
  Protein Sci, 7, 1477-1480.  
9800204 C.M.Thomas, M.S.Dixon, M.Parniske, C.Golstein, and J.D.Jones (1998).
Genetic and molecular analysis of tomato Cf genes for resistance to Cladosporium fulvum.
  Philos Trans R Soc Lond B Biol Sci, 353, 1413-1424.  
9789264 G.Del Giudice, M.Pizza, and R.Rappuoli (1998).
Molecular basis of vaccination.
  Mol Aspects Med, 19, 1.  
9636063 S.Miller, B.Schuler, and R.Seckler (1998).
A reversibly unfolding fragment of P22 tailspike protein with native structure: the isolated beta-helix domain.
  Biochemistry, 37, 9160-9168.  
9241431 C.Chothia, T.Hubbard, S.Brenner, H.Barns, and A.Murzin (1997).
Protein folds in the all-beta and all-alpha classes.
  Annu Rev Biophys Biomol Struct, 26, 597-627.  
9204285 J.Heringa, and W.R.Taylor (1997).
Three-dimensional domain duplication, swapping and stealing.
  Curr Opin Struct Biol, 7, 416-421.  
15012275 K.E.Hammond-Kosack, and J.D.Jones (1997).
PLANT DISEASE RESISTANCE GENES.
  Annu Rev Plant Physiol Plant Mol Biol, 48, 575-607.  
9115442 T.N.Petersen, S.Kauppinen, and S.Larsen (1997).
The crystal structure of rhamnogalacturonase A from Aspergillus aculeatus: a right-handed parallel beta helix.
  Structure, 5, 533-544.
PDB code: 1rmg
8946845 B.Kobe (1996).
Leucines on a roll.
  Nat Struct Biol, 3, 977-980.  
9027346 J.J.Remy, L.Couture, J.Pantel, T.Haertlé, H.Rabesona, V.Bozon, E.Pajot-Augy, P.Robert, F.Troalen, R.Salesse, and J.M.Bidart (1996).
Mapping of HCG-receptor complexes.
  Mol Cell Endocrinol, 125, 79-91.  
8900122 N.Kita, C.M.Boyd, M.R.Garrett, F.Jurnak, and N.T.Keen (1996).
Differential effect of site-directed mutations in pelC on pectate lyase activity, plant tissue maceration, and elicitor activity.
  J Biol Chem, 271, 26529-26535.  
8855221 S.Steinbacher, U.Baxa, S.Miller, A.Weintraub, R.Seckler, and R.Huber (1996).
Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors.
  Proc Natl Acad Sci U S A, 93, 10584-10588.
PDB codes: 1tyu 1tyv 1tyw 1tyx
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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