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UniProt functional annotation for Q60900 | ||
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| UniProt code: Q60900. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10734193, PubMed:9016658). May also bind poly-A tracts via RRM 3 (PubMed:9016658). May be involved in neuronal differentiation and maintenance (PubMed:9016658). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (PubMed:11573004). {ECO:0000269|PubMed:10734193, ECO:0000269|PubMed:11573004, ECO:0000269|PubMed:9016658, ECO:0000303|PubMed:9016658}. |
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| Subunit: | |
Interacts with MAP1B light chain LC1. {ECO:0000269|PubMed:21288476}. |
| Tissue specificity: | |
Brain specific (PubMed:9016658). Expressed in the hippocampus with expression in CA1, CA3 and dentate gyrus (PubMed:11573004). {ECO:0000269|PubMed:11573004, ECO:0000269|PubMed:9016658}. |
| Induction: | |
Up-regulated after spatial learning in radial arm maze experiments and in Morris water maze experiments. {ECO:0000269|PubMed:11573004}. |
| Domain: | |
RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences. {ECO:0000269|PubMed:10734193, ECO:0000269|PubMed:9016658}. |
| Disruption phenotype: | |
RNAi-mediated knockdown results in reduced Gap43 mRNA levels and impaired learning behavior in radial arm maze training. {ECO:0000269|PubMed:11573004}. |
| Similarity: | |
Belongs to the RRM elav family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.