|
|
||
|
|
|
|
|
UniProt functional annotation for P21856 | ||
|
|
|
|
|
|
||
| UniProt code: P21856. |
|
||
| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
|
||
|
||
| Function: | |
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:11208110, ECO:0000269|PubMed:12623022}. |
|
||
| Subunit: | |
Interacts with RHOH (By similarity). Interacts with the non- phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity). Interacts with RAB3A (PubMed:8609986). {ECO:0000250|UniProtKB:P31150, ECO:0000269|PubMed:8609986}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Golgi apparatus, trans- Golgi network {ECO:0000250}. |
| Similarity: | |
Belongs to the Rab GDI family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.