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UniProt functional annotation for P01050 | ||
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| UniProt code: P01050. |
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| Organism: | |
Hirudo medicinalis (Medicinal leech). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata; Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Hirudo. |
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| Function: | |
Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. {ECO:0000269|PubMed:17585879}. |
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| Subcellular location: | |
Secreted. |
| Pharmaceutical: | |
Available under the name Refludan (Hoechst Marion Roussel). Used to treat heparin-induced thrombocytopenia (HIT). |
| Similarity: | |
Belongs to the protease inhibitor I14 (hirudin) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.