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UniProt functional annotation for P49410 | ||
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| UniProt code: P49410. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. {ECO:0000250|UniProtKB:P49411}. |
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| Subunit: | |
Interacts with NLRX1. Interacts with ATG16L1. {ECO:0000250|UniProtKB:P49411}. |
| Subcellular location: | |
Mitochondrion {ECO:0000250|UniProtKB:P49411}. |
| Similarity: | |
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}. |
Annotations taken from UniProtKB at the EBI.