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UniProt functional annotation for P08799 | ||
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| UniProt code: P08799. |
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| Organism: | |
Dictyostelium discoideum (Slime mold). |
| Taxonomy: | |
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium. |
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| Function: | |
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. |
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| Subunit: | |
Myosin-2 heavy chain is two-headed. It self-assembles into filaments. Hexamer of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Associates with elmoA. |
| Subcellular location: | |
Cytoplasm, cell cortex. Note=Highest concentration in the posterior cell cortex. |
| Domain: | |
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). {ECO:0000305}. |
| Domain: | |
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. |
| Ptm: | |
Phosphorylation inhibits thick filament formation and reduces the actin-activated ATPase activity. {ECO:0000269|PubMed:2387408, ECO:0000269|PubMed:2828113}. |
| Miscellaneous: | |
Dictyostelium myosin-2 has no K(2)EDTA ATPase activity, perhaps correlated with the absence of a Cys at the SH-1 position (688). |
| Similarity: | |
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.