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UniProt functional annotation for P67966 | ||
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| UniProt code: P67966. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression. {ECO:0000269|PubMed:8294495}. |
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| Subunit: | |
Probable monomer. Interacts with ZYX. {ECO:0000269|PubMed:1469049, ECO:0000269|PubMed:8294495}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:P21291}. Cytoplasm {ECO:0000269|PubMed:8294495}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8294495}. Note=Associates with the actin cytoskeleton. {ECO:0000269|PubMed:8294495}. |
| Tissue specificity: | |
Most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine. Lower level in the heart, no expression in liver, skeletal muscle, or brain. {ECO:0000269|PubMed:8294495}. |
| Developmental stage: | |
Expression levels increase dramatically during smooth muscle maturation. |
| Domain: | |
Glycine-rich repeats mediate the association with the actin cytoskeleton. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.