UniProt functional annotation for P00968

UniProt code: P00968.

Organism: Escherichia coli (strain K12).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Catalytic activity: 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
Cofactor: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 4 Mn(2+) ions per subunit.;
Pathway: Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Subunit: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.
Similarity: Belongs to the CarB family. {ECO:0000305}.
Similarity: Contains 2 ATP-grasp domains. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.