UniProt functional annotation for P62157



	UniProt functional annotation for P62157

UniProt codes: P62157, P02593.

Organism: Bos taurus (Bovine).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.

Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). {ECO:0000250}.

Subunit: Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (PubMed:11457842, PubMed:8022785). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). {ECO:0000250|UniProtKB:P0DP23, ECO:0000250|UniProtKB:P62158, ECO:0000250|UniProtKB:P62204, ECO:0000269|PubMed:11457842, ECO:0000269|PubMed:8022785}.

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.

Ptm: Ubiquitination results in a strongly decreased activity. {ECO:0000269|PubMed:9716384}.

Ptm: Phosphorylation results in a decreased activity. {ECO:0000250}.

Miscellaneous: This protein has four functional calcium-binding sites.

Similarity: Belongs to the calmodulin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Bos taurus (Bovine).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.



Function:		Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). {ECO:0000250}.


Subunit:		Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (PubMed:11457842, PubMed:8022785). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). {ECO:0000250\|UniProtKB:P0DP23, ECO:0000250\|UniProtKB:P62158, ECO:0000250\|UniProtKB:P62204, ECO:0000269\|PubMed:11457842, ECO:0000269\|PubMed:8022785}.
Subcellular location:		Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.
Ptm:		Ubiquitination results in a strongly decreased activity. {ECO:0000269\|PubMed:9716384}.
Ptm:		Phosphorylation results in a decreased activity. {ECO:0000250}.
Miscellaneous:		This protein has four functional calcium-binding sites.
Similarity:		Belongs to the calmodulin family. {ECO:0000305}.