PDBsum entry 1cmg

Calcium-binding protein

PDB id: 1cmg

Contents

Protein chain

73 a.a.

References listed in PDB file

Key reference

• Title: Calcium-Induced structural changes and domain autonomy in calmodulin.
• Authors: B.E.Finn, J.Evenäs, T.Drakenberg, J.P.Waltho, E.Thulin, S.Forsén.
• Ref.: Nat Struct Biol, 1995, 2, 777-783.
• PubMed id: 7552749

Abstract

We have determined the solution structures of the apo and (Ca2+)2 forms of the carboxy-terminal domain of calmodulin using multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The results show that both forms adopt well-defined structures with essentially equal secondary structure. A comparison of the structures of the two forms shows that Ca2+ binding causes major rearrangements of the secondary structure elements with changes in inter-residue distances of up to 15 A and exposure of the hydrophobic interior of the four-helix bundle. Comparisons with previously determined high-resolution X-ray structures and models of calmodulin indicate that this domain is structurally autonomous.

Secondary reference #1

• Title: The structure of apo-Calmodulin. A 1h nmr examination of the carboxy-Terminal domain.
• Authors: B.E.Finn, T.Drakenberg, S.Forsén.
• Ref.: FEBS Lett, 1993, 336, 368-374. [DOI no: 10.1016/0014-5793(93)80839-M]
• PubMed id: 8262263