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PDBsum entry 1cmg
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Calcium-binding protein
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PDB id
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1cmg
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Contents |
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* Residue conservation analysis
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Nat Struct Biol
2:777-783
(1995)
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PubMed id:
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Calcium-induced structural changes and domain autonomy in calmodulin.
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B.E.Finn,
J.Evenäs,
T.Drakenberg,
J.P.Waltho,
E.Thulin,
S.Forsén.
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ABSTRACT
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We have determined the solution structures of the apo and (Ca2+)2 forms of the
carboxy-terminal domain of calmodulin using multidimensional heteronuclear
nuclear magnetic resonance spectroscopy. The results show that both forms adopt
well-defined structures with essentially equal secondary structure. A comparison
of the structures of the two forms shows that Ca2+ binding causes major
rearrangements of the secondary structure elements with changes in inter-residue
distances of up to 15 A and exposure of the hydrophobic interior of the
four-helix bundle. Comparisons with previously determined high-resolution X-ray
structures and models of calmodulin indicate that this domain is structurally
autonomous.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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I.V.Korendovych,
D.W.Kulp,
Y.Wu,
H.Cheng,
H.Roder,
and
W.F.DeGrado
(2011).
Design of a switchable eliminase.
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Proc Natl Acad Sci U S A,
108,
6823-6827.
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PDB code:
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M.Muik,
M.Fahrner,
R.Schindl,
P.Stathopulos,
I.Frischauf,
I.Derler,
P.Plenk,
B.Lackner,
K.Groschner,
M.Ikura,
and
C.Romanin
(2011).
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.
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EMBO J,
30,
1678-1689.
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W.Ohashi,
H.Hirota,
and
T.Yamazaki
(2011).
Solution structure and fluctuation of the Mg(2+)-bound form of calmodulin C-terminal domain.
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Protein Sci,
20,
690-701.
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PDB code:
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J.L.Kitevski-Leblanc,
F.Evanics,
and
R.Scott Prosser
(2010).
Approaches to the assignment of (19)F resonances from 3-fluorophenylalanine labeled calmodulin using solution state NMR.
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J Biomol NMR,
47,
113-123.
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N.Hayashi,
and
K.Titani
(2010).
N-myristoylated proteins, key components in intracellular signal transduction systems enabling rapid and flexible cell responses.
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Proc Jpn Acad Ser B Phys Biol Sci,
86,
494-508.
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C.Li,
J.Chan,
F.Haeseleer,
K.Mikoshiba,
K.Palczewski,
M.Ikura,
and
J.B.Ames
(2009).
Structural Insights into Ca2+-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1.
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J Biol Chem,
284,
2472-2481.
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E.Laine,
A.Blondel,
and
T.E.Malliavin
(2009).
Dynamics and energetics: a consensus analysis of the impact of calcium on EF-CaM protein complex.
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Biophys J,
96,
1249-1263.
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I.Bertini,
S.Das Gupta,
X.Hu,
T.Karavelas,
C.Luchinat,
G.Parigi,
and
J.Yuan
(2009).
Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states.
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J Biol Inorg Chem,
14,
1097-1107.
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PDB codes:
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S.Dobney,
D.Chiasson,
P.Lam,
S.P.Smith,
and
W.A.Snedden
(2009).
The calmodulin-related calcium sensor CML42 plays a role in trichome branching.
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J Biol Chem,
284,
31647-31657.
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S.L.Shirran,
and
P.E.Barran
(2009).
The use of ESI-MS to probe the binding of divalent cations to calmodulin.
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J Am Soc Mass Spectrom,
20,
1159-1171.
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B.Kim,
and
A.Chilkoti
(2008).
Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding.
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J Am Chem Soc,
130,
17867-17873.
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D.Fan,
R.Lakshminarayanan,
and
J.Moradian-Oldak
(2008).
The 32kDa enamelin undergoes conformational transitions upon calcium binding.
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J Struct Biol,
163,
109-115.
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E.Laine,
J.D.Yoneda,
A.Blondel,
and
T.E.Malliavin
(2008).
The conformational plasticity of calmodulin upon calcium complexation gives a model of its interaction with the oedema factor of Bacillus anthracis.
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Proteins,
71,
1813-1829.
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P.M.Mohan,
S.Mukherjee,
and
K.V.Chary
(2008).
Differential native state ruggedness of the two Ca2+-binding domains in a Ca2+ sensor protein.
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Proteins,
70,
1147-1153.
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Q.Guo,
J.E.Jureller,
J.T.Warren,
E.Solomaha,
J.Florián,
and
W.J.Tang
(2008).
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
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J Biol Chem,
283,
23836-23845.
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J.T.Warren,
Q.Guo,
and
W.J.Tang
(2007).
A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
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J Mol Biol,
374,
517-527.
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PDB code:
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M.R.Yun,
N.Mousseau,
and
P.Derreumaux
(2007).
Sampling small-scale and large-scale conformational changes in proteins and molecular complexes.
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J Chem Phys,
126,
105101.
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Y.Zhou,
W.P.Tzeng,
W.Yang,
Y.Zhou,
Y.Ye,
H.W.Lee,
T.K.Frey,
and
J.Yang
(2007).
Identification of a Ca2+-binding domain in the rubella virus nonstructural protease.
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J Virol,
81,
7517-7528.
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A.Houdusse,
J.F.Gaucher,
E.Krementsova,
S.Mui,
K.M.Trybus,
and
C.Cohen
(2006).
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features.
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Proc Natl Acad Sci U S A,
103,
19326-19331.
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PDB code:
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F.Capozzi,
F.Casadei,
and
C.Luchinat
(2006).
EF-hand protein dynamics and evolution of calcium signal transduction: an NMR view.
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J Biol Inorg Chem,
11,
949-962.
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I.André,
T.Kesvatera,
B.Jönsson,
and
S.Linse
(2006).
Salt enhances calmodulin-target interaction.
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Biophys J,
90,
2903-2910.
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J.M.Shifman,
M.H.Choi,
S.Mihalas,
S.L.Mayo,
and
M.B.Kennedy
(2006).
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums.
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Proc Natl Acad Sci U S A,
103,
13968-13973.
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L.Milanesi,
C.A.Hunter,
S.E.Sedelnikova,
and
J.P.Waltho
(2006).
Amplification of bifunctional ligands for calmodulin from a dynamic combinatorial library.
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Chemistry,
12,
1081-1087.
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M.T.Naik,
N.Suree,
U.Ilangovan,
C.K.Liew,
W.Thieu,
D.O.Campbell,
J.J.Clemens,
M.E.Jung,
and
R.T.Clubb
(2006).
Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop.
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J Biol Chem,
281,
1817-1826.
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P.Radivojac,
S.Vucetic,
T.R.O'Connor,
V.N.Uversky,
Z.Obradovic,
and
A.K.Dunker
(2006).
Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition.
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Proteins,
63,
398-410.
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T.Q.Le,
M.Gochin,
J.D.Featherstone,
W.Li,
and
P.K.DenBesten
(2006).
Comparative calcium binding of leucine-rich amelogenin peptide and full-length amelogenin.
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Eur J Oral Sci,
114,
320.
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X.Zhang,
T.Zou,
Y.Liu,
and
Y.Qi
(2006).
The gating effect of calmodulin and calcium on the connexin50 hemichannel.
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Biol Chem,
387,
595-601.
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I.Horváth,
V.Harmat,
A.Perczel,
V.Pálfi,
L.Nyitray,
A.Nagy,
E.Hlavanda,
G.Náray-Szabó,
and
J.Ovádi
(2005).
The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug.
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J Biol Chem,
280,
8266-8274.
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PDB code:
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K.A.Young,
and
J.H.Caldwell
(2005).
Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.
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J Physiol,
565,
349-370.
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P.Lundström,
F.A.Mulder,
and
M.Akke
(2005).
Correlated dynamics of consecutive residues reveal transient and cooperative unfolding of secondary structure in proteins.
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Proc Natl Acad Sci U S A,
102,
16984-16989.
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P.Lundström,
and
M.Akke
(2005).
Microsecond protein dynamics measured by 13Calpha rotating-frame spin relaxation.
|
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Chembiochem,
6,
1685-1692.
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P.Lundström,
and
M.Akke
(2005).
Off-resonance rotating-frame amide proton spin relaxation experiments measuring microsecond chemical exchange in proteins.
|
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J Biomol NMR,
32,
163-173.
|
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I.Bertini,
C.Del Bianco,
I.Gelis,
N.Katsaros,
C.Luchinat,
G.Parigi,
M.Peana,
A.Provenzani,
and
M.A.Zoroddu
(2004).
Experimentally exploring the conformational space sampled by domain reorientation in calmodulin.
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Proc Natl Acad Sci U S A,
101,
6841-6846.
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PDB code:
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W.Zhou,
Y.Qian,
K.Kunjilwar,
P.J.Pfaffinger,
and
S.Choe
(2004).
Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels.
|
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Neuron,
41,
573-586.
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PDB code:
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C.S.Brinkworth,
J.A.Carver,
K.L.Wegener,
J.Doyle,
L.E.Llewellyn,
and
J.H.Bowie
(2003).
The solution structure of frenatin 3, a neuronal nitric oxide synthase inhibitor from the giant tree frog, Litoria infrafrenata.
|
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Biopolymers,
70,
424-434.
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M.M.Zhu,
D.L.Rempel,
J.Zhao,
D.E.Giblin,
and
M.L.Gross
(2003).
Probing Ca2+-induced conformational changes in porcine calmodulin by H/D exchange and ESI-MS: effect of cations and ionic strength.
|
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Biochemistry,
42,
15388-15397.
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M.Nagae,
A.Nozawa,
N.Koizumi,
H.Sano,
H.Hashimoto,
M.Sato,
and
T.Shimizu
(2003).
The crystal structure of the novel calcium-binding protein AtCBL2 from Arabidopsis thaliana.
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J Biol Chem,
278,
42240-42246.
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PDB code:
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S.W.Vetter,
and
E.Leclerc
(2003).
Novel aspects of calmodulin target recognition and activation.
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Eur J Biochem,
270,
404-414.
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G.Li,
and
Q.Cui
(2002).
A coarse-grained normal mode approach for macromolecules: an efficient implementation and application to Ca(2+)-ATPase.
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Biophys J,
83,
2457-2474.
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J.B.Ames,
N.Hamasaki,
and
T.Molchanova
(2002).
Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.
|
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Biochemistry,
41,
5776-5787.
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PDB code:
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J.Doyle,
L.E.Llewellyn,
C.S.Brinkworth,
J.H.Bowie,
K.L.Wegener,
T.Rozek,
P.A.Wabnitz,
J.C.Wallace,
and
M.J.Tyler
(2002).
Amphibian peptides that inhibit neuronal nitric oxide synthase. Isolation of lesuerin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri.
|
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Eur J Biochem,
269,
100-109.
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J.Elezgaray,
G.Marcou,
and
Y.H.Sanejouand
(2002).
Exploring the natural conformational changes of the C-terminal domain of calmodulin.
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Phys Rev E Stat Nonlin Soft Matter Phys,
66,
031908.
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L.S.Mizoue,
and
W.J.Chazin
(2002).
Engineering and design of ligand-induced conformational change in proteins.
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Curr Opin Struct Biol,
12,
459-463.
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M.R.Nelson,
E.Thulin,
P.A.Fagan,
S.Forsén,
and
W.J.Chazin
(2002).
The EF-hand domain: a globally cooperative structural unit.
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Protein Sci,
11,
198-205.
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PDB code:
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N.Hayashi,
M.Matsubara,
Y.Jinbo,
K.Titani,
Y.Izumi,
and
N.Matsushima
(2002).
Nef of HIV-1 interacts directly with calcium-bound calmodulin.
|
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Protein Sci,
11,
529-537.
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S.R.Martin,
and
P.M.Bayley
(2002).
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V.
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Protein Sci,
11,
2909-2923.
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Y.Shen,
Y.S.Lee,
S.Soelaiman,
P.Bergson,
D.Lu,
A.Chen,
K.Beckingham,
Z.Grabarek,
M.Mrksich,
and
W.J.Tang
(2002).
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
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EMBO J,
21,
6721-6732.
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PDB code:
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D.Vigil,
S.C.Gallagher,
J.Trewhella,
and
A.E.García
(2001).
Functional dynamics of the hydrophobic cleft in the N-domain of calmodulin.
|
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Biophys J,
80,
2082-2092.
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G.Larsson,
J.Schleucher,
J.Onions,
S.Hermann,
T.Grundström,
and
S.S.Wijmenga
(2001).
A novel target recognition revealed by calmodulin in complex with the basic helix--loop--helix transcription factor SEF2-1/E2-2.
|
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Protein Sci,
10,
169-186.
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J.J.Chou,
S.Li,
C.B.Klee,
and
A.Bax
(2001).
Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.
|
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Nat Struct Biol,
8,
990-997.
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PDB codes:
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M.Akke,
and
W.J.Chazin
(2001).
An open and shut case.
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Nat Struct Biol,
8,
910-912.
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N.Benaroudj,
E.Tarcsa,
P.Cascio,
and
A.L.Goldberg
(2001).
The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes.
|
| |
Biochimie,
83,
311-318.
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Z.Qin,
and
T.C.Squier
(2001).
Calcium-dependent stabilization of the central sequence between Met(76) and Ser(81) in vertebrate calmodulin.
|
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Biophys J,
81,
2908-2918.
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D.Yin,
H.Sun,
D.A.Ferrington,
and
T.C.Squier
(2000).
Closer proximity between opposing domains of vertebrate calmodulin following deletion of Met(145)-Lys(148).
|
| |
Biochemistry,
39,
10255-10268.
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H.Ishida,
K.Takahashi,
K.Nakashima,
Y.Kumaki,
M.Nakata,
K.Hikichi,
and
M.Yazawa
(2000).
Solution structures of the N-terminal domain of yeast calmodulin: Ca2+-dependent conformational change and its functional implication.
|
| |
Biochemistry,
39,
13660-13668.
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PDB codes:
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J.L.Enmon,
T.de Beer,
and
M.Overduin
(2000).
Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
|
| |
Biochemistry,
39,
4309-4319.
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PDB code:
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L.Masino,
S.R.Martin,
and
P.M.Bayley
(2000).
Ligand binding and thermodynamic stability of a multidomain protein, calmodulin.
|
| |
Protein Sci,
9,
1519-1529.
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N.Hayashi,
Y.Izumi,
K.Titani,
and
N.Matsushima
(2000).
The binding of myristoylated N-terminal nonapeptide from neuro-specific protein CAP-23/NAP-22 to calmodulin does not induce the globular structure observed for the calmodulin-nonmyristylated peptide complex.
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| |
Protein Sci,
9,
1905-1913.
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S.Fefeu,
R.R.Biekofsky,
J.E.McCormick,
S.R.Martin,
P.M.Bayley,
and
J.Feeney
(2000).
Calcium-induced refolding of the calmodulin V136G mutant studied by NMR spectroscopy: evidence for interaction between the two globular domains.
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| |
Biochemistry,
39,
15920-15931.
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S.R.Martin,
L.Masino,
and
P.M.Bayley
(2000).
Enhancement by Mg2+ of domain specificity in Ca2+-dependent interactions of calmodulin with target sequences.
|
| |
Protein Sci,
9,
2477-2488.
|
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S.Y.Lee,
and
R.E.Klevit
(2000).
The whole is not the simple sum of its parts in calmodulin from S. cerevisiae.
|
| |
Biochemistry,
39,
4225-4230.
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T.Berggård,
M.Silow,
E.Thulin,
and
S.Linse
(2000).
Ca(2+)- and H(+)-dependent conformational changes of calbindin D(28k).
|
| |
Biochemistry,
39,
6864-6873.
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PDB code:
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Where a reference describes a PDB structure, the PDB
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