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UniProt functional annotation for P0A7D4 | ||
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| UniProt code: P0A7D4. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000255|HAMAP-Rule:MF_00011}. |
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| Catalytic activity: | |
Reaction=GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2- dicarboxyethyl)-AMP + phosphate; Xref=Rhea:RHEA:15753, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57567, ChEBI:CHEBI:58053, ChEBI:CHEBI:58189; EC=6.3.4.4; Evidence={ECO:0000255|HAMAP- Rule:MF_00011}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| Pathway: | |
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00011}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_00011, ECO:0000269|PubMed:10346917, ECO:0000269|PubMed:8961938, ECO:0000269|PubMed:9000627}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the adenylosuccinate synthetase family. {ECO:0000255|HAMAP-Rule:MF_00011}. |
Annotations taken from UniProtKB at the EBI.