UniProt functional annotation for P20241



	UniProt functional annotation for P20241

UniProt code: P20241.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. {ECO:0000269|PubMed:1693086}.

Subunit: Forms a complex with Nrx and Cont. {ECO:0000269|PubMed:15459097}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.

Tissue specificity: Long isoform is restricted to surface of neurons and glia in the developing nervous system and the short isoform to other non-neuronal tissues. {ECO:0000269|PubMed:1693086}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. {ECO:0000269\|PubMed:1693086}.


Subunit:		Forms a complex with Nrx and Cont. {ECO:0000269\|PubMed:15459097}.
Subcellular location:		Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Tissue specificity:		Long isoform is restricted to surface of neurons and glia in the developing nervous system and the short isoform to other non-neuronal tissues. {ECO:0000269\|PubMed:1693086}.