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PDBsum entry 1cfb
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Neural adhesion molecule
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PDB id
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1cfb
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References listed in PDB file
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Key reference
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Title
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Crystal structure of tandem type III fibronectin domains from drosophila neuroglian at 2.0 a.
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Authors
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A.H.Huber,
Y.M.Wang,
A.J.Bieber,
P.J.Bjorkman.
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Ref.
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Neuron, 1994,
12,
717-731.
[DOI no: ]
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PubMed id
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Abstract
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We report the crystal structure of two adjacent fibronectin type III repeats
from the Drosophila neural cell adhesion molecule neuroglian. Each domain
consists of two antiparallel beta sheets and is folded topologically identically
to single fibronectin type III domains from the extracellular matrix proteins
tenascin and fibronectin. beta bulges and left-handed polyproline II helices
disrupt the regular beta sheet structure of both neuroglian domains. The
hydrophobic interdomain interface includes a metal-binding site, presumably
involved in stabilizing the relative orientation between domains and predicted
by sequence comparision to be present in the vertebrate homolog molecule L1. The
neuroglian domains are related by a near perfect 2-fold screw axis along the
longest molecular dimension. Using this relationship, a model for arrays of
tandem fibronectin type III repeats in neuroglian and other molecules is
proposed.
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Secondary reference #1
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Title
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Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule l1.
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Authors
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A.J.Bieber,
P.M.Snow,
M.Hortsch,
N.H.Patel,
J.R.Jacobs,
Z.R.Traquina,
J.Schilling,
C.S.Goodman.
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Ref.
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Cell, 1989,
59,
447-460.
[DOI no: ]
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PubMed id
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