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PDBsum entry 1cec
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Hydrolase (glycosyl)
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PDB id
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1cec
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References listed in PDB file
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Key reference
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Title
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A common protein fold and similar active site in two distinct families of beta-Glycanases.
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Authors
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R.Dominguez,
H.Souchon,
S.Spinelli,
Z.Dauter,
K.S.Wilson,
S.Chauvaux,
P.Béguin,
P.M.Alzari.
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Ref.
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Nat Struct Biol, 1995,
2,
569-576.
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PubMed id
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Abstract
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The structure of Clostridium thermocellum endoglucanase CelC, a member of the
largest cellulase family (family A), has been determined at 2.15 A resolution.
The protein folds into an (alpha/beta)8 barrel, with a deep active-site cleft
generated by the insertion of a helical subdomain. The structure of the
catalytic core of xylanase XynZ, which belongs to xylanase family F, has been
determined at 1.4 A resolution. In spite of significant differences in substrate
specificity and structure (including the absence of the helical subdomain), the
general polypeptide folding pattern, architecture of the active site and
catalytic mechanism of XynZ and CelC are similar, suggesting a common
evolutionary origin.
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Secondary reference #1
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Title
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Characterization of two crystal forms of clostridium thermocellum endoglucanase celc.
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Authors
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R.Dominguez,
H.Souchon,
P.M.Alzari.
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Ref.
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Proteins, 1994,
19,
158-160.
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PubMed id
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