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UniProt functional annotation for Q8AV97 | ||
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| UniProt code: Q8AV97. |
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| Organism: | |
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops. |
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| Function: | |
Strong platelet aggregation inhibitor. Binds specifically to platelet glycoprotein Ibalpha (GP1BA) with high affinity and inhibits vWF-dependent platelet aggregation (PubMed:7599152). Has also been observed to induce small agglutinates in washed platelets by binding to GPIb (PubMed:10688335). {ECO:0000269|PubMed:10688335, ECO:0000269|PubMed:7599152}. |
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| Subunit: | |
Tetramer of heterodimers of alpha and beta subunits (alphabeta)(4); disulfide-linked. {ECO:0000269|PubMed:10684640}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Miscellaneous: | |
Has no effect on ADP- and collagen-induced platelet aggregation in platelet rich plasma. {ECO:0000305|PubMed:7599152}. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.