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UniProt functional annotation for P08419 | ||
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| UniProt code: P08419. |
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| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
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| Function: | |
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. {ECO:0000250|UniProtKB:P08217}. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.; EC=3.4.21.71; Evidence={ECO:0000250|UniProtKB:P08217}; |
| Subunit: | |
Interacts with CPA1. Interacts with SERPINA1. {ECO:0000250|UniProtKB:P08217}. |
| Subcellular location: | |
Secreted {ECO:0000250|UniProtKB:P08217}. |
| Tissue specificity: | |
Pancreas. |
| Similarity: | |
Belongs to the peptidase S1 family. Elastase subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.