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PDBsum entry 1bnh
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Ribonuclease inhibitor
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PDB id
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1bnh
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Nature
366:751-756
(1993)
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PubMed id:
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Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats.
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B.Kobe,
J.Deisenhofer.
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ABSTRACT
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Ribonuclease inhibitor is a cytoplasmic protein that tightly binds and inhibits
ribonucleases of the pancreatic ribonuclease superfamily. The primary sequence
of this inhibitor contains leucine-rich repeats (LRRs); these motifs are present
in many proteins that participate in protein-protein interactions and have
different functions and cellular locations. In vivo, ribonuclease inhibitor may
have a role in the regulation of RNA turnover in mammalian cells and in
angiogenesis. To define the structural features of LRR proteins and to
understand better the nature of the tight interaction of ribonuclease inhibitor
with ribonucleases, we have determined the crystal structure of the porcine
inhibitor. To our knowledge, this is the first three-dimensional structure of a
protein containing LRRs and represents a new class of alpha/beta protein fold.
Individual repeats constitute beta-alpha structural units that probably also
occur in other proteins containing LRRs. The non-globular shape of the structure
and the exposed face of the parallel beta-sheet may explain why LRRs are used to
achieve strong protein-protein interactions. A possible ribonuclease-binding
region incorporates the surface formed by the parallel beta-sheet and the beta
alpha loops.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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PDB codes:
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PDB code:
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
|
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