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PDBsum entry 1bj8
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References listed in PDB file
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Key reference
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Title
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The signal transducer gp130: solution structure of the carboxy-Terminal domain of the cytokine receptor homology region.
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Authors
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T.Kernebeck,
S.Pflanz,
G.Müller-Newen,
G.Kurapkat,
R.M.Scheek,
K.Dijkstra,
P.C.Heinrich,
A.Wollmer,
S.Grzesiek,
J.Grötzinger.
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Ref.
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Protein Sci, 1999,
8,
5.
[DOI no: ]
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PubMed id
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Abstract
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The transmembrane glycoprotein gp130 is the common signal transducing receptor
subunit of the interleukin-6-type cytokines. It is a member of the
cytokine-receptor superfamily predicted to consist of six domains in its
extracellular part. The second and third domain constitute the cytokine-binding
module defined by a set of four conserved cysteines and a WSXWS motif,
respectively. The three-dimensional structure of the carboxy-terminal domain of
this region was determined by multidimensional NMR. The domain consists of seven
beta-strands constituting a fibronectin type III-like topology. The structure
reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine
zipper which modulates the conformation of the CD loop.
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Secondary reference #1
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Title
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The signal transducer gp130--Bacterial expression, Refolding and properties of the carboxy-Terminal domain of the cytokine-Binding module.
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Authors
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G.Müller-Newen,
S.Pflanz,
U.Hassiepen,
J.Stahl,
A.Wollmer,
P.C.Heinrich,
J.Grötzinger.
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Ref.
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Eur J Biochem, 1997,
247,
425-431.
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PubMed id
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