PDBsum entry 1bj8

Receptor

PDB id: 1bj8

Contents

Protein chain

109 a.a. *

* Residue conservation analysis

PDB id:

1bj8

Name:

Receptor

Title:

Third n-terminal domain of gp130, nmr, minimized average structure

Structure:

Gp130. Chain: a. Fragment: third n-terminal domain. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

NMR struc:

1 models

Authors:

T.Kernebeck,S.Pflanz,G.Muller-Newen,G.Kurapkat,R.M.Scheek,K.Dijkstra, P.C.Heinrich,A.Wollmer,S.Grzesiek,J.Grotzinger

Key ref:

T.Kernebeck et al. (1999). The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region. Protein Sci, 8, 5. PubMed id: 10210178 DOI: 10.1110/ps.8.1.5

Date:

02-Jul-98 Release date: 13-Jan-99

Protein chain

P40189  (IL6RB_HUMAN) -  Interleukin-6 receptor subunit beta from Homo sapiens

Seq: 918 a.a.

Struc: 109 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1110/ps.8.1.5

Protein Sci 8:5 (1999)

PubMed id: 10210178

The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.

T.Kernebeck, S.Pflanz, G.Müller-Newen, G.Kurapkat, R.M.Scheek, K.Dijkstra, P.C.Heinrich, A.Wollmer, S.Grzesiek, J.Grötzinger.

ABSTRACT

The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.