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PDBsum entry 1bfc
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Growth factor
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PDB id
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1bfc
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References listed in PDB file
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Key reference
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Title
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Heparin structure and interactions with basic fibroblast growth factor.
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Authors
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S.Faham,
R.E.Hileman,
J.R.Fromm,
R.J.Linhardt,
D.C.Rees.
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Ref.
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Science, 1996,
271,
1116-1120.
[DOI no: ]
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
perfect match.
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Abstract
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Crystal structures of heparin-derived tetra- and hexasaccharides complexed with
basic fibroblast growth factor (bFGF) were determined at resolutions of 1.9 and
2.2 angstroms, respectively. The heparin structure may be approximated as a
helical polymer with a disaccharide rotation of 174 degrees and a translation of
8.6 angstroms along the helix axis. Both molecules bound similarly to a region
of the bFGF surface containing residues asparagine-28, arginine-121, lysine-126,
and glutamine-135, the hexasaccharide also interacted with an additional binding
site formed by lysine-27, asparagine-102, and lysine-136. No significant
conformational change in bFGF occurred upon heparin oligosaccharide binding,
which suggests that heparin primarily serves to juxtapose components of the FGF
signal transduction pathway.
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Secondary reference #1
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Title
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Three-Dimensional structures of acidic and basic fibroblast growth factors.
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Authors
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X.Zhu,
H.Komiya,
A.Chirino,
S.Faham,
G.M.Fox,
T.Arakawa,
B.T.Hsu,
D.C.Rees.
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Ref.
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Science, 1991,
251,
90-93.
[DOI no: ]
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PubMed id
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