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UniProt functional annotation for Q00420 | ||
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| UniProt code: Q00420. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:25200183). Acts as a a master regulator of nuclear-encoded mitochondrial genes (PubMed:25200183). {ECO:0000269|PubMed:25200183}. |
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| Subunit: | |
Heterotetramer of two alpha and two beta subunits (PubMed:25200183). Interacts with HCFC1, causing repression of transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q06547, ECO:0000269|PubMed:25200183}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:Q06547}. |
| Ptm: | |
Acetylated by EP300/p300 (PubMed:25200183). Deacetylated by SIRT7, promoting heterotetramerization and activity (PubMed:25200183). {ECO:0000269|PubMed:25200183}. |
| Miscellaneous: | |
[Isoform 3]: May be due to competing acceptor splice sites. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 4]: May be due to an intron retention. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.