|
|
||
|
|
|
|
|
UniProt functional annotation for P10037 | ||
|
|
|
|
|
|
||
| UniProt code: P10037. |
|
||
| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
|
||
|
||
| Function: | |
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. {ECO:0000250|UniProtKB:P28069}. |
|
||
| Subunit: | |
Interacts with PITX1. Interacts with LHX3. Interacts with ELK1. {ECO:0000250|UniProtKB:P28069}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:P28069}. |
| Miscellaneous: | |
[Isoform A]: Altered in its ability to trans-activate compared to isoform B. {ECO:0000305}. |
| Similarity: | |
Belongs to the POU transcription factor family. Class-1 subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA41851.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA41853.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.