|
|
||
|
|
|
|
|
UniProt functional annotation for P41361 | ||
|
|
|
|
|
|
||
| UniProt code: P41361. |
|
||
| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
|
||
|
||
| Function: | |
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). {ECO:0000250}. |
|
||
| Subunit: | |
Forms protease inhibiting heterodimer with TMPRSS7. {ECO:0000250}. |
| Subcellular location: | |
Secreted, extracellular space {ECO:0000250}. |
| Tissue specificity: | |
Plasma. |
| Ptm: | |
Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P01008}. |
| Similarity: | |
Belongs to the serpin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.