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PDBsum entry 1apt

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Hydrolase/hydrolase inhibitor PDB id
1apt
Contents
Protein chain
323 a.a. *
Ligands
IVA-VAL-VAL-LTA
MAN
Waters ×247
* Residue conservation analysis

References listed in PDB file
Key reference
Title Crystallographic analysis of a pepstatin analogue binding to the aspartyl proteinase penicillopepsin at 1.8 angstroms resolution
Authors M.N.G.James, A.R.Sielecki, J.Moult.
Ref. peptides: structure and, 1983, 1, 521.
Secondary reference #1
Title Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- And difluorostatone-Containing peptides.
Authors M.N.James, A.R.Sielecki, K.Hayakawa, M.H.Gelb.
Ref. Biochemistry, 1992, 31, 3872-3886. [DOI no: 10.1021/bi00130a019]
PubMed id 1567842
Full text Abstract
Secondary reference #2
Title Aspartic proteinases and their catalytic pathway
Authors M.N.G.James, A.R.Sielecki.
Ref. biological macromolecules, 1987, 3, 414.
Secondary reference #3
Title Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin.
Authors M.N.James, A.R.Sielecki.
Ref. Biochemistry, 1985, 24, 3701-3713. [DOI no: 10.1021/bi00335a045]
PubMed id 3899173
Full text Abstract
Secondary reference #4
Title X-Ray diffraction studies on penicillopepsin and its complexes: the hydrolytic mechanism
Authors M.N.G.James, A.R.Sielecki, T.Hofmann.
Ref. aspartic proteinases and ...
Secondary reference #5
Title Effect of ph on the activities of penicillopepsin and rhizopus pepsin and a proposal for the productive substrate binding mode in penicillopepsin
Authors T.Hofmann, R.S.Hodges, M.N.G.James.
Ref. biochemistry, 1984, 23, 635.
Secondary reference #6
Title Structure and refinement of penicillopepsin at 1.8 angstroms resolution
Authors M.N.G.James, A.R.Sielecki.
Ref. j mol biol, 1983, 163, 299.
Secondary reference #7
Title Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.
Authors M.N.James, A.Sielecki, F.Salituro, D.H.Rich, T.Hofmann.
Ref. Proc Natl Acad Sci U S A, 1982, 79, 6137-6141. [DOI no: 10.1073/pnas.79.20.6137]
PubMed id 6755464
Full text Abstract
PROCHECK
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