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PDBsum entry 1aoj
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Signal transduction
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PDB id
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1aoj
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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The sh3 domain of eps8 exists as a novel intertwined dimer.
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Authors
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K.V.Kishan,
G.Scita,
W.T.Wong,
P.P.Di fiore,
M.E.Newcomer.
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Ref.
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Nat Struct Biol, 1997,
4,
739-743.
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PubMed id
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Abstract
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SH3 domains are structurally well-characterized as monomeric modular units of
protein structure that mediate protein-protein recognition in numerous signal
transduction proteins. The X-ray crystallographic structure of the Eps8 SH3
domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from
Eps8 is a dimer formed by strand interchange. In addition,
co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo.
Hence, the SH3 domain of Eps8 may represent a dimerization motif.
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Secondary reference #1
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Title
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Eps8, A substrate for the epidermal growth factor receptor kinase, Enhances egf-Dependent mitogenic signals.
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Authors
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F.Fazioli,
L.Minichiello,
V.Matoska,
P.Castagnino,
T.Miki,
W.T.Wong,
P.P.Di fiore.
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Ref.
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Embo J, 1993,
12,
3799-3808.
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PubMed id
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