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Contents |
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274 a.a.
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100 a.a.
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115 a.a.
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209 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Complex (mhc/viral peptide/receptor)
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Title:
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Complex between human t-cell receptor, viral peptide (tax), and hla-a 0201
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Structure:
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Hla-a 0201. Chain: a. Fragment: extracellular domains alpha 1, alpha 2, alpha 3. Synonym: hla-a2 heavy chain. Engineered: yes. Beta-2 microglobulin. Chain: b. Engineered: yes. Mutation: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: plasma. Cellular_location: plasma membrane. Gene: hla-a 0201. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Biol. unit:
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Pentamer (from
)
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Resolution:
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2.60Å
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R-factor:
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0.245
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R-free:
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0.320
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Authors:
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D.N.Garboczi,P.Ghosh,U.Utz,Q.R.Fan,W.E.Biddison,D.C.Wiley
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Key ref:
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D.N.Garboczi
et al.
(1996).
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
Nature,
384,
134-141.
PubMed id:
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Date:
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21-Jul-97
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Release date:
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17-Sep-97
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PROCHECK
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Headers
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References
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P04439
(1A03_HUMAN) -
HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
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Seq:
Struc:
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365 a.a.
274 a.a.*
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P61769
(B2MG_HUMAN) -
Beta-2-microglobulin from Homo sapiens
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Seq:
Struc:
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119 a.a.
100 a.a.*
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A0A075B6T6
(TVAL2_HUMAN) -
T cell receptor alpha variable 12-2 from Homo sapiens
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Seq:
Struc:
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113 a.a.
115 a.a.*
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P01848
(TCA_HUMAN) -
T cell receptor alpha chain constant from Homo sapiens
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Seq:
Struc:
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140 a.a.
115 a.a.*
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Nature
384:134-141
(1996)
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PubMed id:
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| |
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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
|
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D.N.Garboczi,
P.Ghosh,
U.Utz,
Q.R.Fan,
W.E.Biddison,
D.C.Wiley.
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ABSTRACT
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Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major
histocompatibility complex (MHC) molecule occurs through variable loops in the
TCR structure which bury almost all the available peptide and a much larger area
of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site
in a surface feature common to all class I and class II MHC molecules, providing
evidence that the nature of binding is general. A broadly applicable binding
mode has implications for the mechanism of repertoire selection and the
magnitude of alloreactions.
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Literature references that cite this PDB file's key reference
|
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.K.Sewell
(2012).
Why must T cells be cross-reactive?
|
| |
Nat Rev Immunol,
12,
669-677.
|
|
|
|
|
|
|
B.Loll,
C.Rückert,
C.S.Hee,
W.Saenger,
B.Uchanska-Ziegler,
and
A.Ziegler
(2011).
Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide.
|
| |
Protein Sci,
20,
278-290.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.H.Aggen,
A.S.Chervin,
F.K.Insaidoo,
K.H.Piepenbrink,
B.M.Baker,
and
D.M.Kranz
(2011).
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
|
| |
Protein Eng Des Sel,
24,
361-372.
|
|
|
|
|
|
|
D.K.Sethi,
D.A.Schubert,
A.K.Anders,
A.Heroux,
D.A.Bonsor,
C.P.Thomas,
E.J.Sundberg,
J.Pyrdol,
and
K.W.Wucherpfennig
(2011).
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
|
| |
J Exp Med,
208,
91.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
|
| |
PLoS One,
6,
e17194.
|
|
|
|
|
|
|
K.W.Wucherpfennig,
and
D.Sethi
(2011).
T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.
|
| |
Semin Immunol,
23,
84-91.
|
|
|
|
|
|
|
R.L.Wong,
B.Liu,
X.Zhu,
L.You,
L.Kong,
K.P.Han,
H.I.Lee,
P.A.Chavaillaz,
M.Jin,
Y.Wang,
P.R.Rhode,
and
H.C.Wong
(2011).
Interleukin-15:Interleukin-15 receptor {alpha} scaffold for creation of multivalent targeted immune molecules.
|
| |
Protein Eng Des Sel,
24,
373-383.
|
|
|
|
|
|
|
S.Gras,
L.Kjer-Nielsen,
Z.Chen,
J.Rossjohn,
and
J.McCluskey
(2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
|
| |
Immunol Cell Biol,
89,
388-395.
|
|
|
|
|
|
|
T.Mallevaey,
A.J.Clarke,
J.P.Scott-Browne,
M.H.Young,
L.C.Roisman,
D.G.Pellicci,
O.Patel,
J.P.Vivian,
J.L.Matsuda,
J.McCluskey,
D.I.Godfrey,
P.Marrack,
J.Rossjohn,
and
L.Gapin
(2011).
A molecular basis for NKT cell recognition of CD1d-self-antigen.
|
| |
Immunity,
34,
315-326.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.J.Czaja
(2010).
Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.
|
| |
Dig Dis Sci,
55,
2712-2726.
|
|
|
|
|
|
|
A.K.Chakraborty,
and
A.Kosmrlj
(2010).
Statistical mechanical concepts in immunology.
|
| |
Annu Rev Phys Chem,
61,
283-303.
|
|
|
|
|
|
|
C.Bluemel,
S.Hausmann,
P.Fluhr,
M.Sriskandarajah,
W.B.Stallcup,
P.A.Baeuerle,
and
P.Kufer
(2010).
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen.
|
| |
Cancer Immunol Immunother,
59,
1197-1209.
|
|
|
|
|
|
|
D.K.Cole,
E.S.Edwards,
K.K.Wynn,
M.Clement,
J.J.Miles,
K.Ladell,
J.Ekeruche,
E.Gostick,
K.J.Adams,
A.Skowera,
M.Peakman,
L.Wooldridge,
D.A.Price,
and
A.K.Sewell
(2010).
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
|
| |
J Immunol,
185,
2600-2610.
|
|
|
|
|
|
|
G.I.van Boxel,
S.Holmes,
L.Fugger,
and
E.Y.Jones
(2010).
An alternative conformation of the T-cell receptor alpha constant region.
|
| |
J Mol Biol,
400,
828-837.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.J.Miles,
A.M.Bulek,
D.K.Cole,
E.Gostick,
A.J.Schauenburg,
G.Dolton,
V.Venturi,
M.P.Davenport,
M.P.Tan,
S.R.Burrows,
L.Wooldridge,
D.A.Price,
P.J.Rizkallah,
and
A.K.Sewell
(2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
|
| |
PLoS Pathog,
6,
e1001198.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.W.Wucherpfennig,
E.Gagnon,
M.J.Call,
E.S.Huseby,
and
M.E.Call
(2010).
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
|
| |
Cold Spring Harb Perspect Biol,
2,
a005140.
|
|
|
|
|
|
|
S.A.Valkenburg,
E.B.Day,
N.G.Swan,
H.A.Croom,
F.R.Carbone,
P.C.Doherty,
S.J.Turner,
and
K.Kedzierska
(2010).
Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8+ T cells.
|
| |
Eur J Immunol,
40,
2470-2481.
|
|
|
|
|
|
|
D.Hatherley,
S.C.Graham,
K.Harlos,
D.I.Stuart,
and
A.N.Barclay
(2009).
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
|
| |
J Biol Chem,
284,
26613-26619.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
| |
J Biol Chem,
284,
27281-27289.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.J.Cragnolini,
N.García-Medel,
and
J.A.de Castro
(2009).
Endogenous processing and presentation of T-cell epitopes from Chlamydia trachomatis with relevance in HLA-B27-associated reactive arthritis.
|
| |
Mol Cell Proteomics,
8,
1850-1859.
|
|
|
|
|
|
|
J.N.Haidar,
B.Pierce,
Y.Yu,
W.Tong,
M.Li,
and
Z.Weng
(2009).
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.
|
| |
Proteins,
74,
948-960.
|
|
|
|
|
|
|
J.Petersen,
S.J.Wurzbacher,
N.A.Williamson,
S.H.Ramarathinam,
H.H.Reid,
A.K.Nair,
A.Y.Zhao,
R.Nastovska,
G.Rudge,
J.Rossjohn,
and
A.W.Purcell
(2009).
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
|
| |
Proc Natl Acad Sci U S A,
106,
2776-2781.
|
|
|
PDB codes:
|
|
|
|
|
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|
|
K.C.Garcia,
J.J.Adams,
D.Feng,
and
L.K.Ely
(2009).
The molecular basis of TCR germline bias for MHC is surprisingly simple.
|
| |
Nat Immunol,
10,
143-147.
|
|
|
|
|
|
|
K.H.Piepenbrink,
O.Y.Borbulevych,
R.F.Sommese,
J.Clemens,
K.M.Armstrong,
C.Desmond,
P.Do,
and
B.M.Baker
(2009).
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.
|
| |
Biochem J,
423,
353-361.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
O.Y.Borbulevych,
K.H.Piepenbrink,
B.E.Gloor,
D.R.Scott,
R.F.Sommese,
D.K.Cole,
A.K.Sewell,
and
B.M.Baker
(2009).
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
|
| |
Immunity,
31,
885-896.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
A.Ziegler,
and
B.Uchanska-Ziegler
(2009).
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.
|
| |
Protein Sci,
18,
37-49.
|
|
|
PDB code:
|
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|
|
|
|
|
|
P.Tolar,
and
S.K.Pierce
(2009).
Change we can believe in--of the conformational type. Workshop on the Initiation of Antigen Receptor Signaling.
|
| |
EMBO Rep,
10,
331-336.
|
|
|
|
|
|
|
S.A.Richman,
D.H.Aggen,
M.L.Dossett,
D.L.Donermeyer,
P.M.Allen,
P.D.Greenberg,
and
D.M.Kranz
(2009).
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.
|
| |
Mol Immunol,
46,
902-916.
|
|
|
|
|
|
|
T.Connelley,
J.Aerts,
A.Law,
and
W.I.Morrison
(2009).
Genomic analysis reveals extensive gene duplication within the bovine TRB locus.
|
| |
BMC Genomics,
10,
192.
|
|
|
|
|
|
|
X.Shang,
L.Wang,
W.Niu,
G.Meng,
X.Fu,
B.Ni,
Z.Lin,
Z.Yang,
X.Chen,
and
Y.Wu
(2009).
Rational optimization of tumor epitopes using in silico analysis-assisted substitution of TCR contact residues.
|
| |
Eur J Immunol,
39,
2248-2258.
|
|
|
|
|
|
|
Y.Chen,
Y.Shi,
H.Cheng,
Y.Q.An,
and
G.F.Gao
(2009).
Structural immunology and crystallography help immunologists see the immune system in action: how T and NK cells touch their ligands.
|
| |
IUBMB Life,
61,
579-590.
|
|
|
|
|
|
|
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity,
28,
304-314.
|
|
|
|
|
|
|
E.J.Adams,
P.Strop,
S.Shin,
Y.H.Chien,
and
K.C.Garcia
(2008).
An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
|
| |
Nat Immunol,
9,
777-784.
|
|
|
|
|
|
|
E.J.Collins,
and
D.S.Riddle
(2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
|
| |
Immunol Res,
41,
267-294.
|
|
|
|
|
|
|
J.Ishizuka,
G.B.Stewart-Jones,
A.van der Merwe,
J.I.Bell,
A.J.McMichael,
and
E.Y.Jones
(2008).
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
|
| |
Immunity,
28,
171-182.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Kedzierska,
N.L.La Gruta,
J.Stambas,
S.J.Turner,
and
P.C.Doherty
(2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
|
| |
Mol Immunol,
45,
607-618.
|
|
|
|
|
|
|
K.M.Armstrong,
K.H.Piepenbrink,
and
B.M.Baker
(2008).
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
|
| |
Biochem J,
415,
183-196.
|
|
|
|
|
|
|
M.A.Cuendet,
and
O.Michielin
(2008).
Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex.
|
| |
Biophys J,
95,
3575-3590.
|
|
|
|
|
|
|
M.A.Exley,
R.Hou,
A.Shaulov,
E.Tonti,
P.Dellabona,
G.Casorati,
O.Akbari,
H.O.Akman,
E.A.Greenfield,
J.E.Gumperz,
J.E.Boyson,
S.P.Balk,
and
S.B.Wilson
(2008).
Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.
|
| |
Eur J Immunol,
38,
1756-1766.
|
|
|
|
|
|
|
M.Cohn
(2008).
An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognition.
|
| |
Immunol Res,
40,
128-147.
|
|
|
|
|
|
|
M.Cohn
(2008).
The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.
|
| |
Mol Immunol,
45,
632-652.
|
|
|
|
|
|
|
M.L.Dustin
(2008).
T-cell activation through immunological synapses and kinapses.
|
| |
Immunol Rev,
221,
77-89.
|
|
|
|
|
|
|
M.L.Dustin
(2008).
Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion.
|
| |
Annu Rev Cell Dev Biol,
24,
577-596.
|
|
|
|
|
|
|
P.Marrack,
J.P.Scott-Browne,
S.Dai,
L.Gapin,
and
J.W.Kappler
(2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
|
| |
Annu Rev Immunol,
26,
171-203.
|
|
|
|
|
|
|
P.Marrack,
K.Rubtsova,
J.Scott-Browne,
and
J.W.Kappler
(2008).
T cell receptor specificity for major histocompatibility complex proteins.
|
| |
Curr Opin Immunol,
20,
203-207.
|
|
|
|
|
|
|
S.Dai,
E.S.Huseby,
K.Rubtsova,
J.Scott-Browne,
F.Crawford,
W.A.Macdonald,
P.Marrack,
and
J.W.Kappler
(2008).
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.
|
| |
Immunity,
28,
324-334.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Z.Kato,
J.N.Stern,
H.K.Nakamura,
K.Kuwata,
N.Kondo,
and
J.L.Strominger
(2008).
Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex.
|
| |
Proc Natl Acad Sci U S A,
105,
15523-15528.
|
|
|
|
|
|
|
Z.Ma,
K.A.Sharp,
P.A.Janmey,
and
T.H.Finkel
(2008).
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
|
| |
PLoS Biol,
6,
e43.
|
|
|
|
|
|
|
A.de Jong,
E.C.Arce,
T.Y.Cheng,
R.P.van Summeren,
B.L.Feringa,
V.Dudkin,
D.Crich,
I.Matsunaga,
A.J.Minnaard,
and
D.B.Moody
(2007).
CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs.
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D.Feng,
C.J.Bond,
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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
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Nat Immunol,
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PDB codes:
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D.Hatherley,
K.Harlos,
D.C.Dunlop,
D.I.Stuart,
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J Biol Chem,
282,
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PDB code:
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D.Masopust,
V.Vezys,
E.J.Wherry,
and
R.Ahmed
(2007).
A brief history of CD8 T cells.
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Eur J Immunol,
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E.Evensen,
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F.E.Tynan,
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J.J.Miles,
M.C.Wilce,
L.Kostenko,
N.A.Borg,
N.A.Williamson,
T.Beddoe,
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S.R.Burrows,
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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
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Nat Immunol,
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PDB codes:
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J.Kuball,
M.L.Dossett,
M.Wolfl,
W.Y.Ho,
R.H.Voss,
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Facilitating matched pairing and expression of TCR chains introduced into human T cells.
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Blood,
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K.M.Armstrong,
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K.R.Jun,
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Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations.
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J Korean Med Sci,
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K.C.Garcia,
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M.A.Cuendet,
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M.Herget,
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Pflugers Arch,
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O.Y.Borbulevych,
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D.J.Powell,
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N.P.Restifo,
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J Mol Biol,
372,
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PDB codes:
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P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
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J Mol Biol,
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PDB codes:
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S.Minguet,
M.Swamy,
B.Alarcón,
I.F.Luescher,
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Immunity,
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Tissue Antigens,
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M.A.Luscher,
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Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.
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Nat Immunol,
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PDB code:
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C.Douat-Casassus,
N.Marchand-Geneste,
E.Diez,
C.Aznar,
P.Picard,
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F.Jotereau,
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Covalent modification of a melanoma-derived antigenic peptide with a natural quinone methide. Preliminary chemical, molecular modelling and immunological evaluation studies.
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Mol Biosyst,
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C.Rückert,
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Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.
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J Biol Chem,
281,
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PDB code:
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C.S.Clements,
M.A.Dunstone,
W.A.Macdonald,
J.McCluskey,
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Polymorphism, natural selection, and structural modeling of class Ia MHC in the African clawed frog (Xenopus laevis).
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Immunogenetics,
58,
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D.K.Cole,
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J.M.Boulter,
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G.F.Gao,
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Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
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Eur J Immunol,
36,
170-179.
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PDB code:
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E.Martinez-Hackert,
N.Anikeeva,
S.A.Kalams,
B.D.Walker,
W.A.Hendrickson,
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Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
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J Biol Chem,
281,
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PDB codes:
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H.J.Wallny,
D.Avila,
L.G.Hunt,
T.J.Powell,
P.Riegert,
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K.Skjødt,
O.Vainio,
F.Vilbois,
M.V.Wiles,
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Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens.
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Proc Natl Acad Sci U S A,
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Identification of a novel HLA-B*44 variant (B*4441) in three unrelated Caucasian individuals.
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Tissue Antigens,
67,
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K.Kedzierska,
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A.W.Purcell,
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Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
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Proc Natl Acad Sci U S A,
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M.H.Andersen,
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Cytotoxic T cells.
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M.Sospedra,
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Molecular mimicry in multiple sclerosis.
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Autoimmunity,
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M.Sospedra,
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Curr Opin Immunol,
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P.D.Baum,
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Nat Methods,
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P.Dokouhaki,
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M.G.Novin,
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Expression profile and clonality of T-cell receptor beta variable genes in normal human endometrium.
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Am J Reprod Immunol,
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P.J.Bjorkman
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Finding the groove.
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Nat Immunol,
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S.D.Gadola,
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N.M.Lissin,
D.Shepherd,
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B.K.Jakobsen,
V.Cerundolo,
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Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
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J Exp Med,
203,
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PDB codes:
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S.J.Davis,
and
P.A.van der Merwe
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The kinetic-segregation model: TCR triggering and beyond.
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Nat Immunol,
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S.J.Turner,
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Structural determinants of T-cell receptor bias in immunity.
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Nat Rev Immunol,
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S.M.Dunn,
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T.Mahon,
B.Cameron,
R.Moysey,
F.Gao,
M.Sami,
J.Boulter,
Y.Li,
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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
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Protein Sci,
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PDB codes:
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Y.Tanaka
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Human gamma delta T cells and tumor immunotherapy.
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J Clin Exp Hematop,
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Z.Wei-Yang,
W.Qian,
H.Zhi-Ming,
M.Min-Jie,
L.Ying,
W.Zhen-Qiang,
H.Xiao-Wei,
W.Ju-Fang,
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Analysis of the CDR3 region of alpha/beta T-cell receptors (TCRs) and TCR BD gene double-stranded recombination signal sequence breaks end in peripheral blood mononuclear cells of T-lineage acute lymphoblastic leukemia.
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Clin Lab Haematol,
28,
405-415.
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B.Laugel,
J.M.Boulter,
N.Lissin,
A.Vuidepot,
Y.Li,
E.Gostick,
L.E.Crotty,
D.C.Douek,
J.Hemelaar,
D.A.Price,
B.K.Jakobsen,
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Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
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J Biol Chem,
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C.Bade-Doeding,
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H.A.Elsner,
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Peptide-binding motif of HLA-A*6603.
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Immunogenetics,
56,
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C.Barassi,
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C.Pastori,
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F.Lillo,
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Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy.
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J Virol,
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D.B.Moody,
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Anatomy of CD1-lipid antigen complexes.
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Nat Rev Immunol,
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D.M.Zajonc,
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D.C.Young,
T.Y.Cheng,
J.Hu,
C.E.Costello,
P.M.Rudd,
R.A.Dwek,
M.J.Miller,
M.B.Brenner,
D.B.Moody,
and
I.A.Wilson
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Molecular mechanism of lipopeptide presentation by CD1a.
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| |
Immunity,
22,
209-219.
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PDB code:
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E.F.Houston,
T.Connelley,
K.Parsons,
N.D.MacHugh,
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Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups.
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Immunogenetics,
57,
674-681.
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E.J.Adams,
Y.H.Chien,
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Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
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Science,
308,
227-231.
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PDB code:
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E.Y.Jones
(2005).
Favorite flavors of surfaces.
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| |
Nat Immunol,
6,
365-366.
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PDB codes:
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|
F.E.Tynan,
S.R.Burrows,
A.M.Buckle,
C.S.Clements,
N.A.Borg,
J.J.Miles,
T.Beddoe,
J.C.Whisstock,
M.C.Wilce,
S.L.Silins,
J.M.Burrows,
L.Kjer-Nielsen,
L.Kostenko,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2005).
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
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| |
Nat Immunol,
6,
1114-1122.
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PDB code:
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|
H.Li,
S.Van Vranken,
Y.Zhao,
Z.Li,
Y.Guo,
L.Eisele,
and
Y.Li
(2005).
Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.
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Protein Sci,
14,
3025-3038.
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PDB codes:
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H.Thude,
C.Hardt,
U.Schorner,
S.Ferencik,
C.Helfricht,
and
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Identification of a new HLA-B allele, HLA-B*4443, in a German family.
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Tissue Antigens,
66,
696-699.
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I.Van Rhijn,
D.M.Zajonc,
I.A.Wilson,
and
D.B.Moody
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T-cell activation by lipopeptide antigens.
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Curr Opin Immunol,
17,
222-229.
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J.C.Huang,
R.J.Ober,
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The central residues of a T cell receptor sequence motif are key determinants of autoantigen recognition in murine experimental autoimmune encephalomyelitis.
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Eur J Immunol,
35,
299-304.
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J.D.Hayball,
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The immune function of MHC class II molecules mutated in the putative superdimer interface.
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Mol Cell Biochem,
273,
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J.L.Chen,
G.Stewart-Jones,
G.Bossi,
N.M.Lissin,
L.Wooldridge,
E.M.Choi,
G.Held,
P.R.Dunbar,
R.M.Esnouf,
M.Sami,
J.M.Boulter,
P.Rizkallah,
C.Renner,
A.Sewell,
P.A.van der Merwe,
B.K.Jakobsen,
G.Griffiths,
E.Y.Jones,
and
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Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
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J Exp Med,
201,
1243-1255.
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PDB codes:
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K.Choudhuri,
D.Wiseman,
M.H.Brown,
K.Gould,
and
P.A.van der Merwe
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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
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Nature,
436,
578-582.
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K.Oved,
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D.Segal,
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Antibody-mediated targeting of human single-chain class I MHC with covalently linked peptides induces efficient killing of tumor cells by tumor or viral-specific cytotoxic T lymphocytes.
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Cancer Immunol Immunother,
54,
867-879.
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Nat Immunol,
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PDB code:
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M.Krogsgaard,
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How T cells 'see' antigen.
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Microsc Res Tech,
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J Biol Chem,
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PDB codes:
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N.A.Borg,
L.K.Ely,
T.Beddoe,
W.A.Macdonald,
H.H.Reid,
C.S.Clements,
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Nat Immunol,
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Tissue Antigens,
66,
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S.H.Hwang,
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M.N.Lee,
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Novel HLA-A*31 allele, A*3111 identified by sequence-based typing.
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Tissue Antigens,
66,
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S.J.Turner,
K.Kedzierska,
H.Komodromou,
N.L.La Gruta,
M.A.Dunstone,
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Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.
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Nat Immunol,
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382-389.
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PDB codes:
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Y.Li,
R.Moysey,
P.E.Molloy,
A.L.Vuidepot,
T.Mahon,
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EMBO J,
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PDB code:
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D.B.Moody,
D.C.Young,
T.Y.Cheng,
J.P.Rosat,
C.Roura-Mir,
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D.M.Zajonc,
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Science,
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J.E.Gumperz
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J.K.Lee,
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K.Harlos,
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T cell cross-reactivity and conformational changes during TCR engagement.
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J Exp Med,
200,
1455-1466.
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PDB codes:
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J.T.Pribila,
A.C.Quale,
K.L.Mueller,
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Proc Natl Acad Sci U S A,
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PDB code:
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M.E.Call,
J.Pyrdol,
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N.A.Watkins,
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Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.
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Tissue Antigens,
63,
345-354.
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PDB code:
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P.A.Wearsch,
C.A.Jakob,
A.Vallin,
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J Biol Chem,
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T.K.Baxter,
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C.F.Suárez,
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Tissue Antigens,
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Immunity,
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PDB code:
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J.W.Yewdell,
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A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
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Immunity,
18,
53-64.
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PDB code:
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M.Bak,
C.Hansen,
N.Tommerup,
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Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor Vbeta domain.
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Proteins,
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A.Achour,
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A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
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Immunity,
17,
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PDB codes:
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A.Kawana-Tachikawa,
M.Tomizawa,
J.Nunoya,
T.Shioda,
A.Kato,
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Glycopeptide specificity of helper T cells obtained in mouse models for rheumatoid arthritis.
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Chembiochem,
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C.S.Clements,
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The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
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D.H.Fremont,
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Structural basis of cytochrome c presentation by IE(k).
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J Exp Med,
195,
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PDB codes:
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E.May,
N.Dulphy,
E.Frauendorf,
R.Duchmann,
P.Bowness,
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Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.
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Tissue Antigens,
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E.R.Unanue
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Imaging immune surveillance by T cells and NK cells.
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Immunol Rev,
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Eur J Immunogenet,
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Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha.
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Protein Sci,
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PDB code:
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H.Sakaguchi,
R.Inoue,
H.Kaneko,
M.Watanabe,
K.Suzuki,
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Interaction among human leucocyte antigen-peptide-T cell receptor complexes in cow's milk allergy: the significance of human leucocyte antigen and T cell receptor-complementarity determining region 3 loops.
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Clin Exp Allergy,
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J.G.Luz,
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Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
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J Exp Med,
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PDB codes:
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J.Hennecke,
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Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
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J Exp Med,
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PDB code:
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K.A.Smith
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Med Immunol,
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Annu Rev Immunol,
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The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy.
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HLA-B*4431: a new HLA-B variant with a complex ancestral history involving HLA-B*44, B*40 and B*07 alleles.
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Molecular mimicry of an HLA-B27-derived ligand of arthritis-linked subtypes with chlamydial proteins.
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L.Gapin,
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PDB code:
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R.Dyall,
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PDB code:
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Y.H.Ding,
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Immunity,
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PDB code:
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Y.Shi,
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Immunity,
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PDB code:
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A.P.West,
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