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UniProt functional annotation for P00508 | ||
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| UniProt code: P00508. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. {ECO:0000250|UniProtKB:P00505}. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=2.6.1.1; Evidence={ECO:0000250|UniProtKB:P00507}; |
| Catalytic activity: | |
Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:1593633, ECO:0000269|PubMed:7903048, ECO:0000269|PubMed:8665890, ECO:0000269|PubMed:8952476}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:1593633, ECO:0000269|PubMed:7903048, ECO:0000269|PubMed:8665890, ECO:0000269|PubMed:8952476}. |
| Subcellular location: | |
Mitochondrion matrix {ECO:0000269|PubMed:8665890}. |
| Tissue specificity: | |
Detected in heart (at protein level). {ECO:0000269|PubMed:8665890}. |
| Miscellaneous: | |
In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. |
| Similarity: | |
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.