PDBsum entry 1ad5

Tyrosine-protein kinase

PDB id: 1ad5

Contents

Protein chains

438 a.a. *

Ligands

ANP ×2

Metals

_CA ×4

* Residue conservation analysis

References listed in PDB file

Key reference

• Title: Crystal structure of the src family tyrosine kinase hck.
• Authors: F.Sicheri, I.Moarefi, J.Kuriyan.
• Ref.: Nature, 1997, 385, 602-609.
• PubMed id: 9024658

Abstract

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.