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UniProt functional annotation for P04117 | ||
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| UniProt code: P04117. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000269|PubMed:12077340, ECO:0000269|PubMed:16574478, ECO:0000269|PubMed:17516629}. |
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| Subunit: | |
Monomer (By similarity). Homodimer. Interacts with PPARG. {ECO:0000250, ECO:0000269|PubMed:12077340, ECO:0000269|PubMed:14594993, ECO:0000269|PubMed:16574478, ECO:0000269|PubMed:17761196, ECO:0000269|PubMed:7929228, ECO:0000269|PubMed:8161548}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:17516629, ECO:0000269|PubMed:17761196}. Nucleus {ECO:0000269|PubMed:17516629, ECO:0000269|PubMed:17761196}. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus (PubMed:17516629). Subject to constitutive nuclear export (PubMed:17516629, PubMed:17761196). {ECO:0000269|PubMed:17516629, ECO:0000269|PubMed:17761196}. |
| Domain: | |
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. |
| Similarity: | |
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.