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UniProt functional annotation for Q01082 | ||
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| UniProt code: Q01082. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
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| Subunit: | |
Interacts with CAMSAP1 (PubMed:24117850). Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Isoform Short cannot bind to the axonal protein fodaxin. {ECO:0000250|UniProtKB:P85986, ECO:0000250|UniProtKB:Q62261, ECO:0000269|PubMed:15262991, ECO:0000269|PubMed:24117850}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250}. |
| Subcellular location: | |
[Isoform 2]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue specificity: | |
Isoform 2 is present in brain, lung and kidney (at protein level). {ECO:0000269|PubMed:11665863}. |
| Similarity: | |
Belongs to the spectrin family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAD92985.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.