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UniProt functional annotation for P13489 | ||
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| UniProt code: P13489. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:14515218, ECO:0000269|PubMed:17292889}. |
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| Subunit: | |
Forms high-affinity heterodimers with RNASE1, ANG and RNASE2. {ECO:0000269|PubMed:15755456, ECO:0000269|PubMed:17350650, ECO:0000269|PubMed:9311977}. |
| Subcellular location: | |
Cytoplasm. |
| Domain: | |
The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side. {ECO:0000269|PubMed:15755456, ECO:0000269|PubMed:17350650, ECO:0000269|PubMed:9311977}. |
| Ptm: | |
The N-terminus is blocked. |
| Ptm: | |
At least 30 of the 32 cysteine residues are in the reduced form. |
Annotations taken from UniProtKB at the EBI.