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UniProt functional annotation for P15445 | ||
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| UniProt code: P15445. |
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| Organism: | |
Naja naja (Indian cobra). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja. |
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| Function: | |
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
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| Catalytic activity: | |
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE- ProRule:PRU10036}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305|PubMed:8419939}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000305|PubMed:8419939}; |
| Subunit: | |
Homotrimer. {ECO:0000269|PubMed:20211188, ECO:0000269|PubMed:8419939, ECO:0000269|PubMed:9636712}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:20203422}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000269|PubMed:20203422}. |
| Miscellaneous: | |
Is not neurotoxic. |
| Similarity: | |
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA45372.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.