PDBsum entry 1y43

Hydrolase

PDB id: 1y43

Contents

Protein chains

32 a.a. *

171 a.a. *

Ligands

SO4 ×5

Waters ×128

* Residue conservation analysis

PDB id:

1y43

Name:

Hydrolase

Title:

Crystal structure of aspergilloglutamic peptidase from aspergillus niger

Structure:

Aspergillopepsin ii light chain. Chain: a. Synonym: acid protease a, proctase a. Aspergillopepsin ii heavy chain. Chain: b. Synonym: acid protease a, proctase a. Ec: 3.4.23.19

Source:

Aspergillus niger var. Macrosporus. Organism_taxid: 29838. Strain: var. Macrosporus. Strain: var. Macrosporus

Biol. unit:

Dimer (from PQS)

Resolution:

1.40Å R-factor: 0.197 R-free: 0.226

Authors:

H.Sasaki,A.Nakagawa,S.Iwata,T.Muramatsu,M.Suganuma,Y.Sawano,M.Kojima, K.Kubota,K.Takahashi

Key ref:

H.Sasaki et al. Crystal structure of aspergilloglutamic peptidase from aspergillus niger. To be published, .

Date:

30-Nov-04 Release date: 13-Dec-05

Protein chain

P24665  (PRTA_ASPNG) -  Aspergillopepsin-2 from Aspergillus niger

Seq: 282 a.a.

Struc: 32 a.a.

Protein chain

P24665  (PRTA_ASPNG) -  Aspergillopepsin-2 from Aspergillus niger

Seq: 282 a.a.

Struc: 171 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.23.19 - aspergillopepsin Ii.
• Reaction: Preferential cleavage in A chain of insulin: 3-Asn-|-Gln-4, 13-Gly-|-Ala-14, and 26-Tyr-|-Thr-27.