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PDBsum entry 1vs1

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protein ligands metals Protein-protein interface(s) links
Transferase PDB id
1vs1
Jmol
Contents
Protein chains
270 a.a. *
Ligands
PEP ×4
Metals
_MN ×4
Waters ×191
* Residue conservation analysis
PDB id:
1vs1
Name: Transferase
Title: Crystal structure of 3-deoxy-d-arabino-heptulosonate-7- phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
Structure: 3-deoxy-7-phosphoheptulonate synthase. Chain: a, b, c, d. Synonym: dahp synthase, phospho-2-dehydro-3-deoxyheptonate aldolase. Engineered: yes
Source: Aeropyrum pernix. Organism_taxid: 56636. Gene: ape0581. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Biol. unit: Tetramer (from PQS)
Resolution:
2.30Å     R-factor:   0.176     R-free:   0.218
Authors: I.A.Shumilin,L.Zhou,J.Wu,R.W.Woodard,R.Bauerle, R.H.Kretsinger
Key ref: I.A.Shumilin et al. Crystal structure of 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep. To be published, .
Date:
09-Mar-06     Release date:   16-May-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9YEJ7  (Q9YEJ7_AERPE) -  Phospho-2-dehydro-3-deoxyheptonate aldolase
Seq:
Struc:
270 a.a.
270 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.5.1.54  - 3-deoxy-7-phosphoheptulonate synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Shikimate and Chorismate Biosynthesis
      Reaction: Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate
Phosphoenolpyruvate
Bound ligand (Het Group name = PEP)
corresponds exactly
+ D-erythrose 4-phosphate
+ H(2)O
= 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     biosynthetic process   2 terms 
  Biochemical function     catalytic activity     5 terms