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PDBsum entry 1tur
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Serine proteinase inhibitor PDB id
1tur

 

 

 

 

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Contents
Protein chain
56 a.a. *
* Residue conservation analysis
PDB id:
1tur
Name: Serine proteinase inhibitor
Title: Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data
Structure: Ovomucoid. Chain: a. Engineered: yes
Source: Meleagris gallopavo. Turkey. Organism_taxid: 9103
NMR struc: 12 models
Authors: A.M.Krezel,P.Darba,A.D.Robertson,J.Fejzo,S.Macura,J.L.Markley
Key ref: A.M.Krezel et al. (1994). Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data. J Mol Biol, 242, 203-214. PubMed id: 8089842
Date:
06-Jul-94     Release date:   15-Oct-94    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P68390  (IOVO_MELGA) -  Ovomucoid from Meleagris gallopavo
Seq:
Struc: 		185 a.a.
56 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
J Mol Biol 242:203-214 (1994)
PubMed id: 8089842  
 
 
Solution structure of turkey ovomucoid third domain as determined from nuclear magnetic resonance data.
A.M.Krezel, P.Darba, A.D.Robertson, J.Fejzo, S.Macura, J.L.Markley.
 
  ABSTRACT  
 
The solution structure of the 56 amino acid residue turkey ovomucoid third domain was determined by n.m.r. methods. Of the 661 distance constraints used in the calculations, 120 were determined by quadratic approximation of the cross-relaxation rates. The remaining constraints were crudely estimated from a more standard analysis of NOESY spectra. Additionally, 29 torsion angle constraints, 17 hydrogen bonds, and three disulfide bridges were used in the structure calculations. Stereospecific assignments were accomplished for 24 beta-methylene groups and six isopropyl methyl groups (43% chiral assignments). The addition of more accurate distance constraints to the distance geometry/simulated annealing approach resulted in a significant reduction in the dispersion of calculated backbone torsion angles and root-mean-square deviations between structures. Detailed comparisons have been made between the n.m.r. structures of OMTKY3 and published X-ray structures of the same protein and of closely related avian ovomucoid third domains. The refinement with more accurate distance constraints reduced differences between families of the n.m.r. and the X-ray structures.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
16791739 N.Powers, and J.H.Jensen (2006).
Chemically accurate protein structures: validation of protein NMR structures by comparison of measured and predicted pKa values.
  J Biomol NMR, 35, 39-51.  
15473693 K.A.Newton, S.J.Pitteri, M.Laskowski, and S.A.McLuckey (2004).
Effects of single amino acid substitution on the collision-induced dissociation of intact protein ions: Turkey ovomucoid third domain.
  J Proteome Res, 3, 1033-1041.  
  10850807 T.Cierpicki, J.Bania, and J.Otlewski (2000).
NMR solution structure of Apis mellifera chymotrypsin/cathepsin G inhibitor-1 (AMCI-1): structural similarity with Ascaris protease inhibitors.
  Protein Sci, 9, 976-984.
PDB code: 1ccv
10891089 W.R.Forsyth, and A.D.Robertson (2000).
Insensitivity of perturbed carboxyl pK(a) values in the ovomucoid third domain to charge replacement at a neighboring residue.
  Biochemistry, 39, 8067-8072.  
10500144 J.J.Havranek, and P.B.Harbury (1999).
Tanford-Kirkwood electrostatics for protein modeling.
  Proc Natl Acad Sci U S A, 96, 11145-11150.  
  9514268 J.Liu, Y.Gong, O.Prakash, L.Wen, I.Lee, J.K.Huang, and R.Krishnamoorthi (1998).
NMR studies of internal dynamics of serine proteinase protein inhibitors: Binding region mobilities of intact and reactive-site hydrolyzed Cucurbita maxima trypsin inhibitor (CMTI)-III of the squash family and comparison with those of counterparts of CMTI-V of the potato I family.
  Protein Sci, 7, 132-141.  
9628726 W.R.Forsyth, M.K.Gilson, J.Antosiewicz, O.R.Jaren, and A.D.Robertson (1998).
Theoretical and experimental analysis of ionization equilibria in ovomucoid third domain.
  Biochemistry, 37, 8643-8652.  
8672483 J.Antosiewicz, J.A.McCammon, and M.K.Gilson (1996).
The determinants of pKas in proteins.
  Biochemistry, 35, 7819-7833.  
8823186 J.Liu, O.Prakash, Y.Huang, L.Wen, J.J.Wen, J.K.Huang, and R.Krishnamoorthi (1996).
Internal mobility of reactive-site-hydrolyzed recombinant Cucurbita maxima trypsin inhibitor-V characterized by NMR spectroscopy: evidence for differential stabilization of newly formed C- and N-termini.
  Biochemistry, 35, 12503-12510.  
8555171 L.Swint-Kruse, and A.D.Robertson (1996).
Temperature and pH dependences of hydrogen exchange and global stability for ovomucoid third domain.
  Biochemistry, 35, 171-180.  
  8563625 C.G.Hoogstraten, S.Choe, W.M.Westler, and J.L.Markley (1995).
Comparison of the accuracy of protein solution structures derived from conventional and network-edited NOESY data.
  Protein Sci, 4, 2289-2299.
PDB codes: 1omt 1omu
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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