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PDBsum entry 1rsz

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protein ligands links
Transferase PDB id
1rsz
Jmol
Contents
Protein chain
282 a.a. *
Ligands
SO4 ×3
DIH
Waters ×63
* Residue conservation analysis
PDB id:
1rsz
Name: Transferase
Title: Structure of human purine nucleoside phosphorylase in comple dadme-immucillin-h and sulfate
Structure: Purine nucleoside phosphorylase. Chain: a. Synonym: inosine phosphorylase, pnp. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: np, pnp. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Trimer (from PDB file)
Resolution:
2.20Å     R-factor:   0.250     R-free:   0.276
Authors: W.Shi,A.Lewandowicz,P.C.Tyler,R.H.Furneaux,S.C.Almo,V.L.Schr
Key ref: W.Shi et al. Structural comparison of human and malarial purine nucleoside phosphorylases. To be published, .
Date:
10-Dec-03     Release date:   22-Feb-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00491  (PNPH_HUMAN) -  Purine nucleoside phosphorylase
Seq:
Struc:
289 a.a.
282 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.4.2.1  - Purine-nucleoside phosphorylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate
2. Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate
Purine nucleoside
Bound ligand (Het Group name = DIH)
matches with 48.00% similarity
+ phosphate
= purine
+ alpha-D-ribose 1-phosphate
Purine deoxynucleoside
+ phosphate
= purine
+ 2'-deoxy-alpha-D-ribose 1-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   5 terms 
  Biological process     small molecule metabolic process   16 terms 
  Biochemical function     catalytic activity     9 terms