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PDBsum entry 1rjn

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protein ligands Protein-protein interface(s) links
Lyase PDB id
1rjn
Jmol
Contents
Protein chains
259 a.a. *
275 a.a. *
245 a.a. *
Ligands
COA
EP1
Waters ×211
* Residue conservation analysis
PDB id:
1rjn
Name: Lyase
Title: The crystal structure of menb (rv0548c) from mycobacterium tuberculosis in complex with the coa portion of naphthoyl c
Structure: Menb. Chain: a, b, c. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: menb (rv0548c). Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Hexamer (from PDB file)
Resolution:
2.30Å     R-factor:   0.197     R-free:   0.225
Authors: J.M.Johnston,V.L.Arcus,E.N.Baker,Tb Structural Genomics Cons (Tbsgc)
Key ref: J.M.Johnston et al. To be published, .
Date:
19-Nov-03     Release date:   30-Nov-04    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam  
P9WNP5  (MENB_MYCTU) -  1,4-dihydroxy-2-naphthoyl-CoA synthase
Seq:
Struc:
314 a.a.
259 a.a.
Protein chain
Pfam  
P9WNP5  (MENB_MYCTU) -  1,4-dihydroxy-2-naphthoyl-CoA synthase
Seq:
Struc:
314 a.a.
275 a.a.
Protein chain
Pfam  
P9WNP5  (MENB_MYCTU) -  1,4-dihydroxy-2-naphthoyl-CoA synthase
Seq:
Struc:
314 a.a.
245 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C: E.C.4.1.3.36  - 1,4-dihydroxy-2-naphthoyl-CoA synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Vitamin K Biosynthesis
      Reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA
=
1,4-dihydroxy-2-naphthoyl-CoA
Bound ligand (Het Group name = COA)
matches with 62.90% similarity
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     plasma membrane   1 term 
  Biological process     metabolic process   3 terms 
  Biochemical function     catalytic activity     3 terms