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PDBsum entry 1lso

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
1lso
Jmol
Contents
Protein chain
291 a.a. *
Ligands
NAD ×2
Waters ×73
* Residue conservation analysis
PDB id:
1lso
Name: Oxidoreductase
Title: Crystal structure of the s137a mutant of l-3-hydroxyacyl- coa dehydrogenase in complex with NAD
Structure: 3-hydroxyacyl-coa dehydrogenase. Chain: a, b. Synonym: l-3-hydroxyacyl-coa dehydrogenase, short chain 3- hydroxyacyl-coa dehydrogenase, hcdh. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hcdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
2.60Å     R-factor:   0.220     R-free:   0.285
Authors: J.J.Barycki,L.J.Banaszak
Key ref: J.J.Barycki and l.j.banaszak Crystal structure of the s137a mutant of l-3-Hydroxyacyl-Coa dehydrogenase in complex with NAD. To be published, .
Date:
17-May-02     Release date:   03-Feb-04    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q16836  (HCDH_HUMAN) -  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Seq:
Struc:
314 a.a.
291 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.35  - 3-hydroxyacyl-CoA dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH
(S)-3-hydroxyacyl-CoA
+
NAD(+)
Bound ligand (Het Group name = NAD)
corresponds exactly
= 3-oxoacyl-CoA
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   6 terms 
  Biological process     small molecule metabolic process   11 terms 
  Biochemical function     oxidoreductase activity     5 terms