PDBsum entry 1jas

Go to PDB code: 
protein links
Ligase PDB id
Protein chain
152 a.a. *
* Residue conservation analysis
PDB id:
Name: Ligase
Title: Hsubc2b
Structure: Ubiquitin-conjugating enzyme e2-17 kda. Chain: a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
NMR struc: 20 models
Authors: T.Miura,W.Klaus,A.Ross,P.Guentert,H.Senn
Key ref: T.Miura et al. (2002). The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. J Biomol NMR, 22, 89-92. PubMed id: 11885984
31-May-01     Release date:   09-Sep-03    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P63146  (UBE2B_HUMAN) -  Ubiquitin-conjugating enzyme E2 B
152 a.a.
152 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.  - Ubiquitin--protein ligase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
+ ubiquitin
+ protein lysine
+ diphosphate
+ protein N-ubiquityllysine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   9 terms 
  Biological process     protein K48-linked ubiquitination   31 terms 
  Biochemical function     nucleotide binding     7 terms  


J Biomol NMR 22:89-92 (2002)
PubMed id: 11885984  
The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.
T.Miura, W.Klaus, A.Ross, P.Güntert, H.Senn.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
21422291 R.G.Hibbert, A.Huang, R.Boelens, and T.K.Sixma (2011).
E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.
  Proc Natl Acad Sci U S A, 108, 5590-5595.
PDB codes: 2yb6 2ybf
15062086 C.Dominguez, A.M.Bonvin, G.S.Winkler, F.M.van Schaik, H.T.Timmers, and R.Boelens (2004).
Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.
  Structure, 12, 633-644.
PDB code: 1ur6
15341722 P.J.Winn, T.L.Religa, J.N.Battey, A.Banerjee, and R.C.Wade (2004).
Determinants of functionality in the ubiquitin conjugating enzyme family.
  Structure, 12, 1563-1574.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.