PDBsum entry 1inc

Hydrolase(serine proteinase)

PDB id: 1inc

Contents

Protein chain

240 a.a. *

Ligands

SO4

ICL

Metals

_CA

Waters ×140

* Residue conservation analysis

PDB id:

1inc

Name:

Hydrolase(serine proteinase)

Title:

Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors

Structure:

Porcine pancreatic elastase. Chain: a. Engineered: yes

Source:

Sus scrofa domestica. Domestic pig. Organism_taxid: 9825. Strain: domestica

Resolution:

1.94Å R-factor: 0.172

Authors:

E.Meyer

Key ref:

R.Radhakrishnan et al. (1987). Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors. J Mol Biol, 198, 417-424. PubMed id: 3430613

Date:

19-Mar-93 Release date: 31-Jan-94

Protein chain

P00772  (CELA1_PIG) -  Chymotrypsin-like elastase family member 1 from Sus scrofa

Seq: 266 a.a.

Struc: 240 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.21.36 - pancreatic elastase.
• Reaction: Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

J Mol Biol 198:417-424 (1987)

PubMed id: 3430613

Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.

R.Radhakrishnan, L.G.Presta, E.F.Meyer, R.Wildonger.

ABSTRACT

The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.