PDBsum entry 1gsg

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protein dna_rna links
Ligase/RNA PDB id
Protein chain
526 a.a.* *
* Residue conservation analysis
* C-alpha coords only
PDB id:
Name: Ligase/RNA
Title: Structure of e.Coli glutaminyl-tRNA synthetase complexed wit and atp at 2.8 angstroms resolution
Structure: Trnagln. Chain: t. Engineered: yes. Glutaminyl-tRNA synthetase. Chain: p. Ec:
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562
2.80Å     R-factor:   0.279    
Authors: M.A.Rould,J.J.Perona,D.Soell,T.A.Steitz
Key ref: M.A.Rould et al. (1989). Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution. Science, 246, 1135-1142. PubMed id: 2479982 DOI: 10.1126/science.2479982
03-Apr-90     Release date:   24-Feb-92    

Protein chain
Pfam   ArchSchema ?
P00962  (SYQ_ECOLI) -  Glutamine--tRNA ligase
554 a.a.
526 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.  - Glutamine--tRNA ligase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl- tRNA(Gln)
+ L-glutamine
+ tRNA(Gln)
+ diphosphate
+ L-glutaminyl- tRNA(Gln)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     translation   5 terms 
  Biochemical function     nucleotide binding     6 terms  


DOI no: 10.1126/science.2479982 Science 246:1135-1142 (1989)
PubMed id: 2479982  
Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution.
M.A.Rould, J.J.Perona, D.Söll, T.A.Steitz.
The crystal structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) and adenosine triphosphate (ATP) has been derived from a 2.8 angstrom resolution electron density map and the known protein and tRNA sequences. The 63.4-kilodalton monomeric enzyme consists of four domains arranged to give an elongated molecule with an axial ratio greater than 3 to 1. Its interactions with the tRNA extend from the anticodon to the acceptor stem along the entire inside of the L of the tRNA. The complexed tRNA retains the overall conformation of the yeast with two major differences: the 3' acceptor strand of tRNA(Gln) makes a hairpin turn toward the inside of the L, with the disruption of the final base pair of the acceptor stem, and the anticodon loop adopts a conformation not seen in any of the previously determined tRNA structures. Specific recognition elements identified so far include (i) enzyme contacts with the 2-amino groups of guanine via the tRNA minor groove in the acceptor stem at G2 and G3; (ii) interactions between the enzyme and the anticodon nucleotides; and (iii) the ability of the nucleotides G73 and U1.A72 of the cognate tRNA to assume a conformation stabilized by the protein at a lower free energy cost than noncognate sequences. The central domain of this synthetase binds ATP, glutamine, and the acceptor end of the tRNA as well as making specific interactions with the acceptor stem.2+t is

Literature references that cite this PDB file's key reference

  PubMed id Reference
22337051 E.A.Dethoff, J.Chugh, A.M.Mustoe, and H.M.Al-Hashimi (2012).
Functional complexity and regulation through RNA dynamics.
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21397189 A.Rodríguez-Hernández, and J.J.Perona (2011).
Heat maps for intramolecular communication in an RNP enzyme encoding glutamine.
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20601684 O.Nureki, P.O'Donoghue, N.Watanabe, A.Ohmori, H.Oshikane, Y.Araiso, K.Sheppard, D.Söll, and R.Ishitani (2010).
Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation.
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PDB code: 3aii
21119764 R.Giegé, and C.Sauter (2010).
Biocrystallography: past, present, future.
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20946981 R.Stefl, F.C.Oberstrass, J.L.Hood, M.Jourdan, M.Zimmermann, L.Skrisovska, C.Maris, L.Peng, C.Hofr, R.B.Emeson, and F.H.Allain (2010).
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
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PDB codes: 2l2j 2l2k 2l3c 2l3j
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Revisiting the operational RNA code for amino acids: Ensemble attributes and their implications.
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Architectural underpinnings of the genetic code for glutamine.
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19098308 G.Sharma, and E.A.First (2009).
Thermodynamic analysis reveals a temperature-dependent change in the catalytic mechanism of bacillus stearothermophilus tyrosyl-tRNA synthetase.
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19379069 J.Ling, N.Reynolds, and M.Ibba (2009).
Aminoacyl-tRNA synthesis and translational quality control.
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19452597 J.M.Schrader, S.J.Chapman, and O.C.Uhlenbeck (2009).
Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis.
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Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition.
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18755841 C.M.Zhang, C.Liu, T.Christian, H.Gamper, J.Rozenski, D.Pan, J.B.Randolph, E.Wickstrom, B.S.Cooperman, and Y.M.Hou (2008).
Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end.
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18548004 H.Xiao, H.Murakami, H.Suga, and A.R.Ferré-D'Amaré (2008).
Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme.
  Nature, 454, 358-361.
PDB codes: 3cul 3cun
18400783 J.Rorbach, A.A.Yusoff, H.Tuppen, D.P.Abg-Kamaludin, Z.M.Chrzanowska-Lightowlers, R.W.Taylor, D.M.Turnbull, R.McFarland, and R.N.Lightowlers (2008).
Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation.
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18160411 N.J.Reiter, L.J.Maher, and S.E.Butcher (2008).
DNA mimicry by a high-affinity anti-NF-kappaB RNA aptamer.
  Nucleic Acids Res, 36, 1227-1236.
PDB code: 2jwv
18310681 S.An, G.Barany, and K.Musier-Forsyth (2008).
Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase.
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18384044 S.Goto-Ito, T.Ito, R.Ishii, Y.Muto, Y.Bessho, and S.Yokoyama (2008).
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5.
  Proteins, 72, 1274-1289.
PDB code: 2yx1
18322459 S.N.Rodin, and A.S.Rodin (2008).
On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases.
  Heredity, 100, 341-355.  
18477696 T.L.Bullock, A.Rodríguez-Hernández, E.M.Corigliano, and J.J.Perona (2008).
A rationally engineered misacylating aminoacyl-tRNA synthetase.
  Proc Natl Acad Sci U S A, 105, 7428-7433.
PDB codes: 2rd2 2re8
17580114 H.Li (2007).
Complexes of tRNA and maturation enzymes: shaping up for translation.
  Curr Opin Struct Biol, 17, 293-301.  
17447878 I.A.Vasil'eva, and N.A.Moor (2007).
Interaction of aminoacyl-tRNA synthetases with tRNA: general principles and distinguishing characteristics of the high-molecular-weight substrate recognition.
  Biochemistry (Mosc), 72, 247-263.  
17284460 M.Deniziak, C.Sauter, H.D.Becker, C.A.Paulus, R.Giegé, and D.Kern (2007).
Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation.
  Nucleic Acids Res, 35, 1421-1431.
PDB code: 2hz7
17202208 M.S.Almeida, M.A.Johnson, T.Herrmann, M.Geralt, and K.Wüthrich (2007).
Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus.
  J Virol, 81, 3151-3161.
PDB codes: 2gdt 2hsx
17028132 S.Yamasaki, S.Nakamura, T.Terada, and K.Shimizu (2007).
Mechanism of the difference in the binding affinity of E. coli tRNAGln to glutaminyl-tRNA synthetase caused by noninterface nucleotides in variable loop.
  Biophys J, 92, 192-200.  
16493477 J.Barman, S.Acharya, C.Zhou, S.Chatterjee, A.Engström, and J.Chattopadhyaya (2006).
Non-identical electronic characters of the internucleotidic phosphates in RNA modulate the chemical reactivity of the phosphodiester bonds.
  Org Biomol Chem, 4, 928-941.  
17110926 K.Suto, Y.Shimizu, K.Watanabe, T.Ueda, S.Fukai, O.Nureki, and K.Tomita (2006).
Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog.
  EMBO J, 25, 5942-5950.
PDB codes: 2dps 2dpt
17074748 M.Bailly, S.Giannouli, M.Blaise, C.Stathopoulos, D.Kern, and H.D.Becker (2006).
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine.
  Nucleic Acids Res, 34, 6083-6094.  
16387655 M.Teplova, Y.R.Yuan, A.T.Phan, L.Malinina, S.Ilin, A.Teplov, and D.J.Patel (2006).
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.
  Mol Cell, 21, 75-85.
PDB codes: 1yty 1zh5
16798914 N.Shen, L.Guo, B.Yang, Y.Jin, and J.Ding (2006).
Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity.
  Nucleic Acids Res, 34, 3246-3258.
PDB codes: 2ake 2dr2
16734422 N.T.Uter, and J.J.Perona (2006).
Active-site assembly in glutaminyl-tRNA synthetase by tRNA-mediated induced fit.
  Biochemistry, 45, 6858-6865.  
17206068 R.Giegé (2006).
The early history of tRNA recognition by aminoacyl-tRNA synthetases.
  J Biosci, 31, 477-488.  
16155584 R.Fukunaga, and S.Yokoyama (2005).
Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition.
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15853794 Y.Chen, and G.Varani (2005).
Protein families and RNA recognition.
  FEBS J, 272, 2088-2097.  
15139817 B.Jayaram, and T.Jain (2004).
The role of water in protein-DNA recognition.
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15576346 C.Köhrer, E.L.Sullivan, and U.L.RajBhandary (2004).
Complete set of orthogonal 21st aminoacyl-tRNA synthetase-amber, ochre and opal suppressor tRNA pairs: concomitant suppression of three different termination codons in an mRNA in mammalian cells.
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15525705 D.J.Rigden (2004).
Archaea recruited D-Tyr-tRNATyr deacylase for editing in Thr-tRNA synthetase.
  RNA, 10, 1845-1851.  
15096594 D.Y.Dubois, M.Blaise, H.D.Becker, V.Campanacci, G.Keith, R.Giegé, C.Cambillau, J.Lapointe, and D.Kern (2004).
An aminoacyl-tRNA synthetase-like protein encoded by the Escherichia coli yadB gene glutamylates specifically tRNAAsp.
  Proc Natl Acad Sci U S A, 101, 7530-7535.  
15096612 J.C.Salazar, A.Ambrogelly, P.F.Crain, J.A.McCloskey, and D.Söll (2004).
A truncated aminoacyl-tRNA synthetase modifies RNA.
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15317795 K.Sakamoto, S.Ishimaru, T.Kobayashi, J.R.Walker, and S.Yokoyama (2004).
The Escherichia coli argU10(Ts) phenotype is caused by a reduction in the cellular level of the argU tRNA for the rare codons AGA and AGG.
  J Bacteriol, 186, 5899-5905.  
15599909 L.Wang, and P.G.Schultz (2004).
Expanding the genetic code.
  Angew Chem Int Ed Engl, 44, 34-66.  
15614972 M.A.Deniziak, C.Sauter, H.D.Becker, R.Giegé, and D.Kern (2004).
Crystallization and preliminary X-ray characterization of the atypical glutaminyl-tRNA synthetase from Deinococcus radiodurans.
  Acta Crystallogr D Biol Crystallogr, 60, 2361-2363.  
15150343 M.Blaise, H.D.Becker, G.Keith, C.Cambillau, J.Lapointe, R.Giegé, and D.Kern (2004).
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon.
  Nucleic Acids Res, 32, 2768-2775.  
15452355 N.T.Uter, and J.J.Perona (2004).
Long-range intramolecular signaling in a tRNA synthetase complex revealed by pre-steady-state kinetics.
  Proc Natl Acad Sci U S A, 101, 14396-14401.  
14764088 R.Banerjee, D.Y.Dubois, J.Gauthier, S.X.Lin, S.Roy, and J.Lapointe (2004).
The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm.
  Eur J Biochem, 271, 724-733.  
14962386 S.Biarrotte-Sorin, A.P.Maillard, J.Delettré, W.Sougakoff, M.Arthur, and C.Mayer (2004).
Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition.
  Structure, 12, 257-267.
PDB codes: 1ne9 1p4n
15489861 S.Hauenstein, C.M.Zhang, Y.M.Hou, and J.J.Perona (2004).
Shape-selective RNA recognition by cysteinyl-tRNA synthetase.
  Nat Struct Mol Biol, 11, 1134-1141.
PDB code: 1u0b
15100435 W.H.McClain, K.Gabriel, D.Lee, and S.Otten (2004).
Structure-function analysis of tRNA(Gln) in an Escherichia coli knockout strain.
  RNA, 10, 795-804.  
14596614 B.E.Nordin, and P.Schimmel (2003).
Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases.
  Biochemistry, 42, 12989-12997.  
14663147 I.Ahel, D.Korencic, M.Ibba, and D.Söll (2003).
Trans-editing of mischarged tRNAs.
  Proc Natl Acad Sci U S A, 100, 15422-15427.  
12737813 J.Cavarelli (2003).
Pushing induced fit to its limits: tRNA-dependent active site assembly in class I aminoacyl-tRNA synthetases.
  Structure, 11, 484-486.  
14602896 K.Takai, and S.Yokoyama (2003).
Roles of 5-substituents of tRNA wobble uridines in the recognition of purine-ending codons.
  Nucleic Acids Res, 31, 6383-6391.  
12737824 L.D.Sherlin, and J.J.Perona (2003).
tRNA-dependent active site assembly in a class I aminoacyl-tRNA synthetase.
  Structure, 11, 591-603.
PDB code: 1nyl
14674776 M.Acchione, J.G.Guillemette, S.M.Twine, C.W.Hogue, B.Rajendran, and A.G.Szabo (2003).
Fluorescence based structural analysis of tryptophan analogue-AMP formation in single tryptophan mutants of Bacillus stearothermophilus tryptophanyl-tRNA synthetase.
  Biochemistry, 42, 14994-15002.  
12554668 S.Sekine, O.Nureki, D.Y.Dubois, S.Bernier, R.Chênevert, J.Lapointe, D.G.Vassylyev, and S.Yokoyama (2003).
ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding.
  EMBO J, 22, 676-688.
PDB codes: 1j09 1n75 1n77 1n78
12754495 T.Kobayashi, O.Nureki, R.Ishitani, A.Yaremchuk, M.Tukalo, S.Cusack, K.Sakamoto, and S.Yokoyama (2003).
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion.
  Nat Struct Biol, 10, 425-432.
PDB code: 1j1u
11983895 A.D.Wolfson, and O.C.Uhlenbeck (2002).
Modulation of tRNAAla identity by inorganic pyrophosphatase.
  Proc Natl Acad Sci U S A, 99, 5965-5970.  
12110594 A.Yaremchuk, I.Kriklivyi, M.Tukalo, and S.Cusack (2002).
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition.
  EMBO J, 21, 3829-3840.
PDB codes: 1h3e 1h3f
11854463 C.A.Myers, B.Kuhla, S.Cusack, and A.M.Lambowitz (2002).
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase.
  Proc Natl Acad Sci U S A, 99, 2630-2635.  
12526808 F.Li, Y.Xiong, J.Wang, H.D.Cho, K.Tomita, A.M.Weiner, and T.A.Steitz (2002).
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.
  Cell, 111, 815-824.
PDB codes: 1miv 1miw 1miy
12032090 K.J.Newberry, Y.M.Hou, and J.J.Perona (2002).
Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase.
  EMBO J, 21, 2778-2787.
PDB codes: 1li5 1li7
12486008 S.B.Rho, T.L.Lincecum, and S.A.Martinis (2002).
An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.
  EMBO J, 21, 6874-6881.  
12427973 X.L.Yang, R.J.Skene, D.E.McRee, and P.Schimmel (2002).
Crystal structure of a human aminoacyl-tRNA synthetase cytokine.
  Proc Natl Acad Sci U S A, 99, 15369-15374.
PDB code: 1n3l
11698642 A.Shimada, O.Nureki, M.Goto, S.Takahashi, and S.Yokoyama (2001).
Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase.
  Proc Natl Acad Sci U S A, 98, 13537-13542.
PDB codes: 1iq0 1ir4
11779468 C.Hoang, and A.R.Ferré-D'Amaré (2001).
Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme.
  Cell, 107, 929-939.
PDB code: 1k8w
11170439 J.F.Chen, T.Li, E.D.Wang, and Y.L.Wang (2001).
Effect of alanine-293 replacement on the activity, ATP binding, and editing of Escherichia coli leucyl-tRNA synthetase.
  Biochemistry, 40, 1144-1149.  
  11720294 L.D.Sherlin, T.L.Bullock, T.A.Nissan, J.J.Perona, F.J.Lariviere, O.C.Uhlenbeck, and S.A.Scaringe (2001).
Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization.
  RNA, 7, 1671-1678.  
11269237 L.Ribas de Pouplana, and P.Schimmel (2001).
Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem.
  Cell, 104, 191-193.  
11590011 L.Ribas de Pouplana, and P.Schimmel (2001).
Aminoacyl-tRNA synthetases: potential markers of genetic code development.
  Trends Biochem Sci, 26, 591-596.  
12762019 O.Nureki, S.Fukai, S.Sekine, A.Shimada, T.Terada, T.Nakama, M.Shirouzu, D.G.Vassylyev, and S.Yokoyama (2001).
Structural basis for amino acid and tRNA recognition by class I aminoacyl-tRNA synthetases.
  Cold Spring Harb Symp Quant Biol, 66, 167-173.  
11600716 T.Tsuji, M.Onimaru, and H.Yanagawa (2001).
Random multi-recombinant PCR for the construction of combinatorial protein libraries.
  Nucleic Acids Res, 29, E97.  
10679466 A.A.Antson (2000).
Single-stranded-RNA binding proteins.
  Curr Opin Struct Biol, 10, 87-94.  
10851193 A.D.Frankel (2000).
Fitting peptides into the RNA world.
  Curr Opin Struct Biol, 10, 332-340.  
11060012 B.Delagoutte, D.Moras, and J.Cavarelli (2000).
tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding.
  EMBO J, 19, 5599-5610.
PDB codes: 1f7u 1f7v
10739930 B.Delagoutte, G.Keith, D.Moras, and J.Cavarelli (2000).
Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes.
  Acta Crystallogr D Biol Crystallogr, 56, 492-494.  
10668794 B.Masquida, and E.Westhof (2000).
On the wobble GoU and related pairs.
  RNA, 6, 9.  
10841758 E.Madore, R.S.Lipman, Y.M.Hou, and J.Lapointe (2000).
Evidence for unfolding of the single-stranded GCCA 3'-End of a tRNA on its aminoacyl-tRNA synthetase from a stacked helical to a foldback conformation.
  Biochemistry, 39, 6791-6798.  
11087829 F.Houman, S.B.Rho, J.Zhang, X.Shen, C.C.Wang, P.Schimmel, and S.A.Martinis (2000).
A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria.
  Proc Natl Acad Sci U S A, 97, 13743-13748.  
10913247 G.Desogus, F.Todone, P.Brick, and S.Onesti (2000).
Active site of lysyl-tRNA synthetase: structural studies of the adenylation reaction.
  Biochemistry, 39, 8418-8425.
PDB codes: 1e1o 1e1t 1e22 1e24
10673435 I.Sugiura, O.Nureki, Y.Ugaji-Yoshikawa, S.Kuwabara, A.Shimada, M.Tateno, B.Lorber, R.Giegé, D.Moras, S.Yokoyama, and M.Konno (2000).
The 2.0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules.
  Structure, 8, 197-208.
PDB code: 1a8h
10828991 J.F.Chen, N.N.Guo, T.Li, E.D.Wang, and Y.L.Wang (2000).
CP1 domain in Escherichia coli leucyl-tRNA synthetase is crucial for its editing function.
  Biochemistry, 39, 6726-6731.  
10821696 J.Wientges, J.Pütz, R.Giegé, C.Florentz, and A.Schwienhorst (2000).
Selection of viral RNA-derived tRNA-like structures with improved valylation activities.
  Biochemistry, 39, 6207-6218.  
10966471 M.Ibba, and D.Soll (2000).
Aminoacyl-tRNA synthesis.
  Annu Rev Biochem, 69, 617-650.  
10696113 M.Lu, and T.A.Steitz (2000).
Structure of Escherichia coli ribosomal protein L25 complexed with a 5S rRNA fragment at 1.8-A resolution.
  Proc Natl Acad Sci U S A, 97, 2023-2028.
PDB code: 1dfu
10744027 R.Geslain, F.Martin, B.Delagoutte, J.Cavarelli, J.Gangloff, and G.Eriani (2000).
In vivo selection of lethal mutations reveals two functional domains in arginyl-tRNA synthetase.
  RNA, 6, 434-448.  
10688361 S.Joseph, M.L.Whirl, D.Kondo, H.F.Noller, and R.B.Altman (2000).
Calculation of the relative geometry of tRNAs in the ribosome from directed hydroxyl-radical probing data.
  RNA, 6, 220-232.  
11041850 S.Onesti, G.Desogus, A.Brevet, J.Chen, P.Plateau, S.Blanquet, and P.Brick (2000).
Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding.
  Biochemistry, 39, 12853-12861.
PDB codes: 1bbu 1bbw
11105758 T.A.Nissan, and J.J.Perona (2000).
Alternative designs for construction of the class II transfer RNA tertiary core.
  RNA, 6, 1585-1596.  
10677223 V.Guez, S.Nair, A.Chaffotte, and H.Bedouelle (2000).
The anticodon-binding domain of tyrosyl-tRNA synthetase: state of folding and origin of the crystallographic disorder.
  Biochemistry, 39, 1739-1747.  
10913310 X.Chen, J.A.McDowell, R.Kierzek, T.R.Krugh, and D.H.Turner (2000).
Nuclear magnetic resonance spectroscopy and molecular modeling reveal that different hydrogen bonding patterns are possible for G.U pairs: one hydrogen bond for each G.U pair in r(GGCGUGCC)(2) and two for each G.U pair in r(GAGUGCUC)(2).
  Biochemistry, 39, 8970-8982.
PDB codes: 1eka 1ekd
10570126 B.A.Steer, and P.Schimmel (1999).
Domain-domain communication in a miniature archaebacterial tRNA synthetase.
  Proc Natl Acad Sci U S A, 96, 13644-13649.  
10213598 B.A.Steer, and P.Schimmel (1999).
Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases.
  Biochemistry, 38, 4965-4971.  
10508782 C.H.Weber, Y.S.Park, S.Sanker, C.Kent, and M.L.Ludwig (1999).
A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from bacillus subtilis.
  Structure, 7, 1113-1124.
PDB code: 1coz
  10348873 C.V.Franklund, and J.B.Goldberg (1999).
Cloning of the glutamyl-tRNA synthetase (gltX) gene from Pseudomonas aeruginosa.
  J Bacteriol, 181, 3582-3586.  
10047585 D.J.Patel (1999).
Adaptive recognition in RNA complexes with peptides and protein modules.
  Curr Opin Struct Biol, 9, 74-87.  
10387013 J.Horowitz, W.C.Chu, W.B.Derrick, J.C.Liu, M.Liu, and D.Yue (1999).
Synthetase recognition determinants of E. coli valine transfer RNA.
  Biochemistry, 38, 7737-7746.  
10216301 K.J.Newberry, J.Kohn, Y.M.Hou, and J.J.Perona (1999).
Crystallization and preliminary diffraction analysis of Escherichia coli cysteinyl-tRNA synthetase.
  Acta Crystallogr D Biol Crystallogr, 55, 1046-1047.  
10518524 K.Y.Chang, G.Varani, S.Bhattacharya, H.Choi, and W.H.McClain (1999).
Correlation of deformability at a tRNA recognition site and aminoacylation specificity.
  Proc Natl Acad Sci U S A, 96, 11764-11769.  
10213600 M.Fromant, P.Plateau, E.Schmitt, Y.Mechulam, and S.Blanquet (1999).
Receptor site for the 5'-phosphate of elongator tRNAs governs substrate selection by peptidyl-tRNA hydrolase.
  Biochemistry, 38, 4982-4987.  
10737860 P.J.Beuning, and K.Musier-Forsyth (1999).
Transfer RNA recognition by aminoacyl-tRNA synthetases.
  Biopolymers, 52, 1.  
10368282 P.Nissen, S.Thirup, M.Kjeldgaard, and J.Nyborg (1999).
The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA.
  Structure, 7, 143-156.
PDB code: 1b23
10319817 R.Sankaranarayanan, A.C.Dock-Bregeon, P.Romby, J.Caillet, M.Springer, B.Rees, C.Ehresmann, B.Ehresmann, and D.Moras (1999).
The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site.
  Cell, 97, 371-381.
PDB code: 1qf6
10587461 R.W.Alexander, and P.Schimmel (1999).
Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex.
  Biochemistry, 38, 16359-16365.  
10371037 S.Commans, and A.Böck (1999).
Selenocysteine inserting tRNAs: an overview.
  FEMS Microbiol Rev, 23, 335-351.  
10562565 S.Eiler, A.Dock-Bregeon, L.Moulinier, J.C.Thierry, and D.Moras (1999).
Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step.
  EMBO J, 18, 6532-6541.
PDB code: 1c0a
10215844 S.Sekine, O.Nureki, M.Tateno, and S.Yokoyama (1999).
The identity determinants required for the discrimination between tRNAGlu and tRNAAsp by glutamyl-tRNA synthetase from Escherichia coli.
  Eur J Biochem, 261, 354-360.  
10094311 T.A.Nissan, B.Oliphant, and J.J.Perona (1999).
An engineered class I transfer RNA with a class II tertiary fold.
  RNA, 5, 434-445.  
10413482 T.Li, Y.Li, N.Guo, E.Wang, and Y.Wang (1999).
Discrimination of tRNALeu isoacceptors by the insertion mutant of Escherichia coli leucyl-tRNA synthetase.
  Biochemistry, 38, 9084-9088.  
10467126 X.Ye, A.Gorin, R.Frederick, W.Hu, A.Majumdar, W.Xu, G.McLendon, A.Ellington, and D.J.Patel (1999).
RNA architecture dictates the conformations of a bound peptide.
  Chem Biol, 6, 657-669.
PDB code: 484d
  9568911 A.K.Mandal, A.Bhattacharyya, S.Bhattacharyya, T.Bhattacharyya, and S.Roy (1998).
A cognate tRNA specific conformational change in glutaminyl-tRNA synthetase and its implication for specificity.
  Protein Sci, 7, 1046-1051.  
10333740 D.J.Patel (1998).
Molecular insights into the RNA world.
  Biopolymers, 48, 97.  
9843487 E.Schmitt, M.Panvert, S.Blanquet, and Y.Mechulam (1998).
Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.
  EMBO J, 17, 6819-6826.
PDB code: 2fmt
9848650 F.Tsai, and J.F.Curran (1998).
tRNA(2Gln) mutants that translate the CGA arginine codon as glutamine in Escherichia coli.
  RNA, 4, 1514-1522.  
  9436909 G.W.Martin, J.W.Harney, and M.J.Berry (1998).
Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide.
  RNA, 4, 65-73.  
9736621 J.Cavarelli, B.Delagoutte, G.Eriani, J.Gangloff, and D.Moras (1998).
L-arginine recognition by yeast arginyl-tRNA synthetase.
  EMBO J, 17, 5438-5448.
PDB code: 1bs2
9518491 J.I.Sagara, S.Shimizu, T.Kawabata, S.Nakamura, M.Ikeguchi, and K.Shimizu (1998).
The use of sequence comparison to detect 'identities' in tRNA genes.
  Nucleic Acids Res, 26, 1974-1979.  
9657697 J.Liu, M.Ibba, K.W.Hong, and D.Söll (1998).
The terminal adenosine of tRNA(Gln) mediates tRNA-dependent amino acid recognition by glutaminyl-tRNA synthetase.
  Biochemistry, 37, 9836-9842.  
9857205 J.M.Ryter, and S.C.Schultz (1998).
Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA.
  EMBO J, 17, 7505-7513.
PDB code: 1di2
9427763 K.Wakasugi, C.L.Quinn, N.Tao, and P.Schimmel (1998).
Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant.
  EMBO J, 17, 297-305.  
9875850 M.P.Horvath, V.L.Schweiker, J.M.Bevilacqua, J.A.Ruggles, and S.C.Schultz (1998).
Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA.
  Cell, 95, 963-974.
PDB code: 1otc
9622124 M.Sissler, R.Giegé, and C.Florentz (1998).
The RNA sequence context defines the mechanistic routes by which yeast arginyl-tRNA synthetase charges tRNA.
  RNA, 4, 647-657.  
9501905 O.C.Uhlenbeck (1998).
A coat for all sequences.
  Nat Struct Biol, 5, 174-176.  
9606201 P.Y.Shi, N.Maizels, and A.M.Weiner (1998).
CCA addition by tRNA nucleotidyltransferase: polymerization without translocation?
  EMBO J, 17, 3197-3206.  
9748544 Q.S.Zhang, E.D.Wang, and Y.L.Wang (1998).
The role of tryptophan residues in Escherichia coli arginyl-tRNA synthetase.
  Biochim Biophys Acta, 1387, 136-142.  
10333745 R.N.De Guzman, R.B.Turner, and M.F.Summers (1998).
Protein-RNA recognition.
  Biopolymers, 48, 181-195.  
9811828 R.S.Lipman, and Y.M.Hou (1998).
Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase.
  Proc Natl Acad Sci U S A, 95, 13495-13500.  
9770466 R.W.Alexander, B.E.Nordin, and P.Schimmel (1998).
Activation of microhelix charging by localized helix destabilization.
  Proc Natl Acad Sci U S A, 95, 12214-12219.  
9671048 S.Lemieux, P.Chartrand, R.Cedergren, and F.Major (1998).
Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme.
  RNA, 4, 739-749.  
9562563 V.L.Rath, L.F.Silvian, B.Beijer, B.S.Sproat, and T.A.Steitz (1998).
How glutaminyl-tRNA synthetase selects glutamine.
  Structure, 6, 439-449.
PDB code: 1qtq
9843398 V.Ramesh, S.Gite, and U.L.RajBhandary (1998).
Functional interaction of an arginine conserved in the sixteen amino acid insertion module of Escherichia coli methionyl-tRNA formyltransferase with determinants for formylation in the initiator tRNA.
  Biochemistry, 37, 15925-15932.  
9435214 W.H.McClain, J.Schneider, S.Bhattacharya, and K.Gabriel (1998).
The importance of tRNA backbone-mediated interactions with synthetase for aminoacylation.
  Proc Natl Acad Sci U S A, 95, 460-465.  
9115984 A.Aberg, A.Yaremchuk, M.Tukalo, B.Rasmussen, and S.Cusack (1997).
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
  Biochemistry, 36, 3084-3094.
PDB codes: 1adj 1ady
9153306 A.Ramos, and G.Varani (1997).
Structure of the acceptor stem of Escherichia coli tRNA Ala: role of the G3.U70 base pair in synthetase recognition.
  Nucleic Acids Res, 25, 2083-2090.
PDB code: 1ikd
9358165 A.U.Metzger, M.Heckl, D.Willbold, K.Breitschopf, U.L.RajBhandary, P.Rösch, and H.J.Gross (1997).
Structural studies on tRNA acceptor stem microhelices: exchange of the discriminator base A73 for G in human tRNALeu switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1-C72 base pair.
  Nucleic Acids Res, 25, 4551-4556.  
9032056 B.F.Clark, and J.Nyborg (1997).
The ternary complex of EF-Tu and its role in protein biosynthesis.
  Curr Opin Struct Biol, 7, 110-116.  
9185564 B.Lustig, S.Arora, and R.L.Jernigan (1997).
RNA base-amino acid interaction strengths derived from structures and sequences.
  Nucleic Acids Res, 25, 2562-2565.  
9222494 C.S.Hamann, and Y.M.Hou (1997).
A strategy of tRNA recognition that includes determinants of RNA structure.
  Bioorg Med Chem, 5, 1011-1019.  
9062123 C.Stehlin, D.H.Heacock, H.Liu, and K.Musier-Forsyth (1997).
Chemical modification and site-directed mutagenesis of the single cysteine in motif 3 of class II Escherichia coli prolyl-tRNA synthetase.
  Biochemistry, 36, 2932-2938.  
9184240 E.F.Whelihan, and P.Schimmel (1997).
Rescuing an essential enzyme-RNA complex with a non-essential appended domain.
  EMBO J, 16, 2968-2974.  
9184155 E.Glasfeld, and P.Schimmel (1997).
Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase.
  Biochemistry, 36, 6739-6744.  
9312034 F.H.Allain, P.W.Howe, D.Neuhaus, and G.Varani (1997).
Structural basis of the RNA-binding specificity of human U1A protein.
  EMBO J, 16, 5764-5772.
PDB code: 1aud
9131996 J.Augustine, and C.Francklyn (1997).
Design of an active fragment of a class II aminoacyl-tRNA synthetase and its significance for synthetase evolution.
  Biochemistry, 36, 3473-3482.  
9174345 J.B.Thoden, H.M.Holden, G.Wesenberg, F.M.Raushel, and I.Rayment (1997).
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
  Biochemistry, 36, 6305-6316.  
9207058 J.G.Arnez, J.G.Augustine, D.Moras, and C.S.Francklyn (1997).
The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
  Proc Natl Acad Sci U S A, 94, 7144-7149.
PDB codes: 1kmm 1kmn
  9426190 J.J.Thiele, M.Podda, and L.Packer (1997).
Tropospheric ozone: an emerging environmental stress to skin.
  Biol Chem, 378, 1299-1305.  
  9372178 J.L.Riechmann, and E.M.Meyerowitz (1997).
MADS domain proteins in plant development.
  Biol Chem, 378, 1079-1101.  
9222493 J.Rudinger, B.Felden, C.Florentz, and R.Giegé (1997).
Strategy for RNA recognition by yeast histidyl-tRNA synthetase.
  Bioorg Med Chem, 5, 1001-1009.  
9261068 K.A.Marshall, M.P.Robertson, and A.D.Ellington (1997).
A biopolymer by any other name would bind as well: a comparison of the ligand-binding pockets of nucleic acids and proteins.
  Structure, 5, 729-734.  
9342332 K.Harada, S.S.Martin, R.Tan, and A.D.Frankel (1997).
Molding a peptide into an RNA site by in vivo peptide evolution.
  Proc Natl Acad Sci U S A, 94, 11887-11892.  
9204274 K.M.Weeks (1997).
Protein-facilitated RNA folding.
  Curr Opin Struct Biol, 7, 336-342.  
9396792 M.Liu, W.C.Chu, J.C.Liu, and J.Horowitz (1997).
Role of acceptor stem conformation in tRNAVal recognition by its cognate synthetase.
  Nucleic Acids Res, 25, 4883-4890.  
9396794 M.Sissler, G.Eriani, F.Martin, R.Giegé, and C.Florentz (1997).
Mirror image alternative interaction patterns of the same tRNA with either class I arginyl-tRNA synthetase or class II aspartyl-tRNA synthetase.
  Nucleic Acids Res, 25, 4899-4906.  
9294151 P.Schimmel, and D.Söll (1997).
When protein engineering confronts the tRNA world.
  Proc Natl Acad Sci U S A, 94, 10007-10009.  
9305643 X.Manival, Y.Yang, M.P.Strub, M.Kochoyan, M.Steinmetz, and S.Aymerich (1997).
From genetic to structural characterization of a new class of RNA-binding domain within the SacY/BglG family of antiterminator proteins.
  EMBO J, 16, 5019-5029.
PDB code: 1auu
9016717 Y.Goldgur, L.Mosyak, L.Reshetnikova, V.Ankilova, O.Lavrik, S.Khodyreva, and M.Safro (1997).
The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
  Structure, 5, 59-68.
PDB code: 1eiy
9190291 Y.M.Hou (1997).
Discriminating among the discriminator bases of tRNAs.
  Chem Biol, 4, 93-96.  
8612277 A.E.Hodel, P.D.Gershon, X.Shi, and F.A.Quiocho (1996).
The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends.
  Cell, 85, 247-256.
PDB code: 1vpt
8555234 A.J.Gale, J.P.Shi, and P.Schimmel (1996).
Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis.
  Biochemistry, 35, 608-615.  
8805509 C.Davies, S.W.White, and V.Ramakrishnan (1996).
The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus.
  Structure, 4, 55-66.
PDB code: 1whi
8916927 D.W.Ohannesian, J.Oh, and Y.M.Hou (1996).
Mutational analysis of a leucine heptad repeat motif in a class I aminoacyl-tRNA synthetase.
  Biochemistry, 35, 14405-14412.  
8672449 E.Glasfeld, J.A.Landro, and P.Schimmel (1996).
C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase.
  Biochemistry, 35, 4139-4145.  
8710865 J.A.Enríquez, and G.Attardi (1996).
Evidence for aminoacylation-induced conformational changes in human mitochondrial tRNAs.
  Proc Natl Acad Sci U S A, 93, 8300-8305.  
8942633 J.G.Arnez, and T.A.Steitz (1996).
Crystal structures of three misacylating mutants of Escherichia coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP.
  Biochemistry, 35, 14725-14733.
PDB codes: 1qrs 1qrt 1qru
8555233 J.M.Sherman, and D.Söll (1996).
Aminoacyl-tRNA synthetases optimize both cognate tRNA recognition and discrimination against noncognate tRNAs.
  Biochemistry, 35, 601-607.  
8652564 J.Tao, and A.D.Frankel (1996).
Arginine-binding RNAs resembling TAR identified by in vitro selection.
  Biochemistry, 35, 2229-2238.  
8602350 K.Breitschopf, and H.J.Gross (1996).
The discriminator bases G73 in human tRNA(Ser) and A73 in tRNA(Leu) have significantly different roles in the recognition of aminoacyl-tRNA synthetases.
  Nucleic Acids Res, 24, 405-410.  
  8617245 K.W.Hong, M.Ibba, I.Weygand-Durasevic, M.J.Rogers, H.U.Thomann, and D.Söll (1996).
Transfer RNA-dependent cognate amino acid recognition by an aminoacyl-tRNA synthetase.
  EMBO J, 15, 1983-1991.  
8736559 L.Jovine, C.Oubridge, J.M.Avis, and K.Nagai (1996).
Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy.
  Structure, 4, 621-631.
PDB code: 3utr
8611551 L.Lin, and P.Schimmel (1996).
Mutational analysis suggests the same design for editing activities of two tRNA synthetases.
  Biochemistry, 35, 5596-5601.  
8679560 L.Ribas de Pouplana, D.S.Auld, S.Kim, and P.Schimmel (1996).
A mechanism for reducing entropic cost of induced fit in protein--RNA recognition.
  Biochemistry, 35, 8095-8102.  
  8654382 M.E.Saks, and J.R.Sampson (1996).
Variant minihelix RNAs reveal sequence-specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl-tRNA synthetase.
  EMBO J, 15, 2843-2849.  
8944770 M.H.Mazauric, J.Reinbolt, B.Lorber, C.Ebel, G.Keith, R.Giegé, and D.Kern (1996).
An example of non-conservation of oligomeric structure in prokaryotic aminoacyl-tRNA synthetases. Biochemical and structural properties of glycyl-tRNA synthetase from Thermus thermophilus.
  Eur J Biochem, 241, 814-826.  
8692925 M.Ibba, K.W.Hong, J.M.Sherman, S.Sever, and D.Söll (1996).
Interactions between tRNA identity nucleotides and their recognition sites in glutaminyl-tRNA synthetase determine the cognate amino acid affinity of the enzyme.
  Proc Natl Acad Sci U S A, 93, 6953-6958.  
8917315 M.Kitabatake, M.Ibba, K.W.Hong, D.Söll, and H.Inokuchi (1996).
Genetic analysis of functional connectivity between substrate recognition domains of Escherichia coli glutaminyl-tRNA synthetase.
  Mol Gen Genet, 252, 717-722.  
8756461 M.Sassanfar, J.E.Kranz, P.Gallant, P.Schimmel, and K.Shiba (1996).
A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug.
  Biochemistry, 35, 9995.  
  8890180 M.Sissler, R.Giegé, and C.Florentz (1996).
Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts.
  EMBO J, 15, 5069-5076.  
8603119 M.Z.Barciszewska, V.A.Erdmann, and J.Barciszewski (1996).
Ribosomal 5S RNA: tertiary structure and interactions with proteins.
  Biol Rev Camb Philos Soc, 71, 1.  
8756460 P.C.Bevilacqua, and T.R.Cech (1996).
Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.
  Biochemistry, 35, 9983-9994.  
8672458 P.Y.Shi, M.A.Brinton, J.M.Veal, Y.Y.Zhong, and W.D.Wilson (1996).
Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA.
  Biochemistry, 35, 4222-4230.  
8555164 R.Aphasizhev, B.Senger, J.U.Rengers, M.Sprinzl, P.Walter, G.Nussbaum, and F.Fasiolo (1996).
Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site.
  Biochemistry, 35, 117-123.  
  8608446 S.A.White, and H.Li (1996).
Yeast ribosomal protein L32 recognizes an RNA G:U juxtaposition.
  RNA, 2, 226-234.  
  8654381 S.Cusack, A.Yaremchuk, and M.Tukalo (1996).
The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site.
  EMBO J, 15, 2834-2842.  
8610114 S.P.Hale, and P.Schimmel (1996).
Protein synthesis editing by a DNA aptamer.
  Proc Natl Acad Sci U S A, 93, 2755-2758.  
8555191 S.Sever, K.Rogers, M.J.Rogers, C.Carter, and D.Söll (1996).
Escherichia coli tryptophanyl-tRNA synthetase mutants selected for tryptophan auxotrophy implicate the dimer interface in optimizing amino acid binding.
  Biochemistry, 35, 32-40.  
8901559 T.W.Dreher, C.H.Tsai, and J.M.Skuzeski (1996).
Aminoacylation identity switch of turnip yellow mosaic virus RNA from valine to methionine results in an infectious virus.
  Proc Natl Acad Sci U S A, 93, 12212-12216.  
  8601277 W.H.McClain, K.Gabriel, and J.Schneider (1996).
Specific function of a G.U wobble pair from an adjacent helical site in tRNA(Ala) during recognition by alanyl-tRNA synthetase.
  RNA, 2, 105-109.  
  8868064 Y.M.Henskens, E.C.Veerman, and A.V.Nieuw Amerongen (1996).
Cystatins in health and disease.
  Biol Chem Hoppe Seyler, 377, 71-86.  
7540304 A.D.Yaremchuk, I.A.Krikliviy, S.Cusack, and M.A.Tukalo (1995).
Cocrystallization of lysyl-tRNA synthetase from Thermus thermophilus with its cognate tRNAlys and with Escherichia coli tRNAlys.
  Proteins, 21, 261-264.  
7479716 A.D.Yaremchuk, S.Cusack, A.Aberg, O.Gudzera, I.Kryklivyi, and M.Tukalo (1995).
Crystallization of Thermus thermophilus histidyl-tRNA synthetase and its complex with tRNAHis.
  Proteins, 22, 426-428.  
7697717 C.D.Mol, A.S.Arvai, G.Slupphaug, B.Kavli, I.Alseth, H.E.Krokan, and J.A.Tainer (1995).
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
  Cell, 80, 869-878.  
7540101 D.Moras, and A.Poterszman (1995).
RNA-protein interactions. Diverse modes of recognition.
  Curr Biol, 5, 249-251.  
  7556056 D.T.Logan, M.H.Mazauric, D.Kern, and D.Moras (1995).
Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus.
  EMBO J, 14, 4156-4167.
PDB code: 1ati
7708493 F.Martin, G.Eriani, J.Reinbolt, G.Dirheimer, and J.Gangloff (1995).
Genetic selection for active E.coli amber tRNA(Asn) exclusively led to glutamine inserting suppressors.
  Nucleic Acids Res, 23, 779-784.  
  7796819 H.Bedouelle, and R.Nageotte (1995).
Macromolecular recognition through electrostatic repulsion.
  EMBO J, 14, 2945-2950.  
7870582 H.Liu, R.Peterson, J.Kessler, and K.Musier-Forsyth (1995).
Molecular recognition of tRNA(Pro) by Escherichia coli proline tRNA synthetase in vitro.
  Nucleic Acids Res, 23, 165-169.  
7533901 H.Ogata, Y.Akiyama, and M.Kanehisa (1995).
A genetic algorithm based molecular modeling technique for RNA stem-loop structures.
  Nucleic Acids Res, 23, 419-426.  
  7556101 H.Urlaub, V.Kruft, O.Bischof, E.C.Müller, and B.Wittmann-Liebold (1995).
Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies.
  EMBO J, 14, 4578-4588.  
7545283 J.Binkley, P.Allen, D.M.Brown, L.Green, C.Tuerk, and L.Gold (1995).
RNA ligands to human nerve growth factor.
  Nucleic Acids Res, 23, 3198-3205.  
  8846773 K.Harada, and A.D.Frankel (1995).
Identification of two novel arginine binding DNAs.
  EMBO J, 14, 5798-5811.  
7761451 L.Chen, and A.D.Frankel (1995).
A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA.
  Proc Natl Acad Sci U S A, 92, 5077-5081.  
7664121 L.Mosyak, L.Reshetnikova, Y.Goldgur, M.Delarue, and M.G.Safro (1995).
Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
  Nat Struct Biol, 2, 537-547.
PDB code: 1pys
7773747 M.Delarue (1995).
Aminoacyl-tRNA synthetases.
  Curr Opin Struct Biol, 5, 48-55.  
7761403 M.W.Friederich, F.U.Gast, E.Vacano, and P.J.Hagerman (1995).
Determination of the angle between the anticodon and aminoacyl acceptor stems of yeast phenylalanyl tRNA in solution.
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Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.
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Selection of suppressor methionyl-tRNA synthetases: mapping the tRNA anticodon binding site.
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  2065667 T.Subramanian, R.Govindarajan, and G.Chinnadurai (1991).
Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation.
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1924390 W.H.McClain, K.Foss, R.A.Jenkins, and J.Schneider (1991).
Four sites in the acceptor helix and one site in the variable pocket of tRNA(Ala) determine the molecule's acceptor identity.
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2068095 W.H.McClain, K.Foss, R.A.Jenkins, and J.Schneider (1991).
Rapid determination of nucleotides that define tRNA(Gly) acceptor identity.
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1992490 Y.M.Hou, K.Shiba, C.Mottes, and P.Schimmel (1991).
Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase.
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2143700 A.D.Cherniack, G.Garriga, J.D.Kittle, R.A.Akins, and A.M.Lambowitz (1990).
Function of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing requires an idiosyncratic domain not found in other synthetases.
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2185472 C.C.Lee, W.J.Craigen, D.M.Muzny, E.Harlow, and C.T.Caskey (1990).
Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.
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2236077 C.Francklyn, and P.Schimmel (1990).
Enzymatic aminoacylation of an eight-base-pair microhelix with histidine.
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1977522 C.R.Kissinger, B.S.Liu, E.Martin-Blanco, T.B.Kornberg, and C.O.Pabo (1990).
Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.
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PDB code: 1hdd
  2253707 D.Söll (1990).
The accuracy of aminoacylation--ensuring the fidelity of the genetic code.
  Experientia, 46, 1089-1096.  
2129559 G.Eriani, G.Dirheimer, and J.Gangloff (1990).
Aspartyl-tRNA synthetase from Escherichia coli: cloning and characterisation of the gene, homologies of its translated amino acid sequence with asparaginyl- and lysyl-tRNA synthetases.
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2203971 G.Eriani, M.Delarue, O.Poch, J.Gangloff, and D.Moras (1990).
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.
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2263446 H.Himeno, T.Hasegawa, T.Ueda, K.Watanabe, and M.Shimizu (1990).
Conversion of aminoacylation specificity from tRNA(Tyr) to tRNA(Ser) in vitro.
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2174366 I.Rubelj, I.Weygand-Durasević, and Z.Kućan (1990).
Evidence for two types of complexes formed by yeast tyrosyl-tRNA synthetase with cognate and non-cognate tRNA. Effect of ribonucleoside triphosphates.
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1694559 I.W.Mattaj (1990).
A selective review of RNA-protein interactions in eukaryotes.
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2290687 J.C.Lacey, and M.P.Staves (1990).
Was there a universal tRNA before specialized tRNAs came into existence?
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1697676 L.Krinke, and D.L.Wulff (1990).
The cleavage specificity of RNase III.
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2263451 M.E.Peter, C.O.Reiser, N.K.Schirmer, T.Kiefhaber, G.Ott, N.W.Grillenbeck, and M.Sprinzl (1990).
Interaction of the isolated domain II/III of Thermus thermophilus elongation factor Tu with the nucleotide exchange factor EF-Ts.
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  2142451 M.H.Jones, and C.Guthrie (1990).
Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site.
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2402434 Q.M.You, and P.J.Romaniuk (1990).
The effects of disrupting 5S RNA helical structures on the binding of Xenopus transcription factor IIIA.
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2194108 T.A.Steitz, M.A.Rould, and J.J.Perona (1990).
Structural basis of tRNA discrimination as derived from the high resolution crystal structure of glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP.
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2204954 T.A.Steitz (1990).
Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding.
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2251270 W.H.McClain, K.Foss, R.A.Jenkins, and J.Schneider (1990).
Nucleotides that determine Escherichia coli tRNA(Arg) and tRNA(Lys) acceptor identities revealed by analyses of mutant opal and amber suppressor tRNAs.
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