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PDBsum entry 1esv

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protein ligands metals Protein-protein interface(s) links
Contractile protein PDB id
1esv
Jmol
Contents
Protein chains
125 a.a. *
359 a.a. *
Ligands
ATP
LAR
Metals
_CA ×3
Waters ×444
* Residue conservation analysis
PDB id:
1esv
Name: Contractile protein
Title: Complex between latrunculin a:rabbit muscle alpha actin:human gelsolin domain 1
Structure: Gelsolin. Chain: s. Fragment: domain 1. Engineered: yes. Mutation: yes. Alpha actin. Chain: a
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: plasma. Expressed in: escherichia coli. Expression_system_taxid: 562. Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986.
Biol. unit: Dimer (from PQS)
Resolution:
2.00Å     R-factor:   0.228     R-free:   0.286
Authors: W.M.Morton,K.A.Ayscough,P.J.Mclaughlin
Key ref: W.M.Morton et al. (2000). Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat Cell Biol, 2, 376-378. PubMed id: 10854330 DOI: 10.1038/35014075
Date:
11-Apr-00     Release date:   19-Jul-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P06396  (GELS_HUMAN) -  Gelsolin
Seq:
Struc:
 
Seq:
Struc:
782 a.a.
125 a.a.*
Protein chain
Pfam   ArchSchema ?
P68135  (ACTS_RABIT) -  Actin, alpha skeletal muscle
Seq:
Struc:
377 a.a.
359 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   5 terms 
  Biological process     skeletal muscle fiber development   2 terms 
  Biochemical function     nucleotide binding     6 terms  

 

 
DOI no: 10.1038/35014075 Nat Cell Biol 2:376-378 (2000)
PubMed id: 10854330  
 
 
Latrunculin alters the actin-monomer subunit interface to prevent polymerization.
W.M.Morton, K.R.Ayscough, P.J.McLaughlin.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21444821 A.R.Paredez, Z.J.Assaf, D.Sept, L.Timofejeva, S.C.Dawson, C.J.Wang, and W.Z.Cande (2011).
An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins.
  Proc Natl Acad Sci U S A, 108, 6151-6156.  
21336301 C.Luxenburg, H.Amalia Pasolli, S.E.Williams, and E.Fuchs (2011).
Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation.
  Nat Cell Biol, 13, 203-214.  
  21275995 Y.Zhang, Y.Xiao, F.Du, L.Cao, H.Dong, and H.Ren (2011).
Arabidopsis VILLIN4 is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner.
  New Phytol, 190, 667-682.  
  20576094 C.Beta (2010).
Bistability in the actin cortex.
  PMC Biophys, 3, 12.  
20479959 F.Silvestre, and E.Tosti (2010).
Impact of marine drugs on cytoskeleton-mediated reproductive events.
  Mar Drugs, 8, 881-915.  
19943905 H.Zou, H.M.Fang, Y.Zhu, and Y.Wang (2010).
Candida albicans Cyr1, Cap1 and G-actin form a sensor/effector apparatus for activating cAMP synthesis in hyphal growth.
  Mol Microbiol, 75, 579-591.  
20043312 M.A.Khanfar, D.T.Youssef, and K.A.El Sayed (2010).
Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: biological evaluations, preliminary structure-activity relationship and molecular modeling studies.
  ChemMedChem, 5, 274-285.  
21061444 M.Tůmová, A.Koffer, M.Simíček, L.Dráberová, and P.Dráber (2010).
The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
  Eur J Immunol, 40, 3235-3245.  
21143319 P.Berndt, D.Lanver, and R.Kahmann (2010).
The AGC Ser/Thr kinase Aga1 is essential for appressorium formation and maintenance of the actin cytoskeleton in the smut fungus Ustilago maydis.
  Mol Microbiol, 78, 1484-1499.  
20403871 P.P.Lie, D.D.Mruk, W.M.Lee, and C.Y.Cheng (2010).
Cytoskeletal dynamics and spermatogenesis.
  Philos Trans R Soc Lond B Biol Sci, 365, 1581-1592.  
20818336 R.Pawłowski, E.K.Rajakylä, M.K.Vartiainen, and R.Treisman (2010).
An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
  EMBO J, 29, 3448-3458.  
20401643 S.Toda, H.Shen, and P.W.Kalivas (2010).
Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbens.
  Neurotox Res, 18, 410-415.  
20334630 Y.Wang, Y.Zhu, Y.Ling, H.Zhang, P.Liu, F.Baluska, J.Samaj, J.Lin, and Q.Wang (2010).
Disruption of actin filaments induces mitochondrial Ca2+ release to the cytoplasm and [Ca2+]c changes in Arabidopsis root hairs.
  BMC Plant Biol, 10, 53.  
19774081 A.Castillo-Romero, G.Leon-Avila, A.Perez Rangel, R.Cortes Zarate, C.Garcia Tovar, and J.M.Hernandez (2009).
Participation of actin on Giardia lamblia growth and encystation.
  PLoS One, 4, e7156.  
19533669 A.Y.Hui, J.A.Meens, C.Schick, S.L.Organ, H.Qiao, E.A.Tremblay, E.Schaeffer, S.Uniyal, B.M.Chan, and B.E.Elliott (2009).
Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells.
  J Cell Biochem, 107, 1168-1181.  
19776349 B.Ponsioen, L.van Zeijl, M.Langeslag, M.Berryman, D.Littler, K.Jalink, and W.H.Moolenaar (2009).
Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.
  Mol Biol Cell, 20, 4664-4672.  
19485537 F.Lin, K.E.Elliott, W.Parker, N.Chakraborty, C.S.Teo, S.T.Smith, G.D.Elliott, and P.J.Moyer (2009).
Confocal and force probe imaging system for simultaneous three-dimensional optical and mechanical spectroscopic evaluation of biological samples.
  Rev Sci Instrum, 80, 055110.  
19700768 G.Silva, V.Jeney, A.Chora, R.Larsen, J.Balla, and M.P.Soares (2009).
Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells.
  J Biol Chem, 284, 29582-29595.  
19605560 J.A.Lopez, J.G.Burchfield, D.H.Blair, K.Mele, Y.Ng, P.Vallotton, D.E.James, and W.E.Hughes (2009).
Identification of a distal GLUT4 trafficking event controlled by actin polymerization.
  Mol Biol Cell, 20, 3918-3929.  
19995729 S.K.Natesan, J.A.Sullivan, and J.C.Gray (2009).
Myosin XI Is Required for Actin-Associated Movement of Plastid Stromules.
  Mol Plant, 2, 1262-1272.  
  20490371 S.M.Kennedy, Z.Ji, N.B.Rockweiler, A.R.Hahn, J.H.Booske, and S.C.Hagness (2009).
The Role of Plasmalemmal-Cortical Anchoring on the Stability of Transmembrane Electropores.
  IEEE Trans Dielectr Electr Insul, 16, 1251-1258.  
19489598 T.L.Simmons, L.M.Nogle, J.Media, F.A.Valeriote, S.L.Mooberry, and W.H.Gerwick (2009).
Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms.
  J Nat Prod, 72, 1011-1016.  
19158791 T.Oda, M.Iwasa, T.Aihara, Y.Maéda, and A.Narita (2009).
The nature of the globular- to fibrous-actin transition.
  Nature, 457, 441-445.
PDB code: 2zwh
19766713 Y.Morot-Gaudry-Talarmain (2009).
Physical and functional interactions of cyclophilin B with neuronal actin and peroxiredoxin-1 are modified by oxidative stress.
  Free Radic Biol Med, 47, 1715-1730.  
18267088 A.Cassidy-Stone, J.E.Chipuk, E.Ingerman, C.Song, C.Yoo, T.Kuwana, M.J.Kurth, J.T.Shaw, J.E.Hinshaw, D.R.Green, and J.Nunnari (2008).
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
  Dev Cell, 14, 193-204.  
18785994 D.Drecktrah, S.Levine-Wilkinson, T.Dam, S.Winfree, L.A.Knodler, T.A.Schroer, and O.Steele-Mortimer (2008).
Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells.
  Traffic, 9, 2117-2129.  
17951576 D.S.Kudryashov, C.L.Cordero, E.Reisler, and K.J.Satchell (2008).
Characterization of the enzymatic activity of the actin cross-linking domain from the Vibrio cholerae MARTX Vc toxin.
  J Biol Chem, 283, 445-452.  
18945676 E.Stokasimov, M.McKane, and P.A.Rubenstein (2008).
Role of intermonomer ionic bridges in the stabilization of the actin filament.
  J Biol Chem, 283, 34844-34854.  
18596213 H.R.Kim, C.Gallant, P.C.Leavis, S.J.Gunst, and K.G.Morgan (2008).
Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent.
  Am J Physiol Cell Physiol, 295, C768-C778.  
18298079 K.A.Sayed, M.A.Khanfar, H.M.Shallal, A.Muralidharan, B.Awate, D.T.Youssef, Y.Liu, Y.D.Zhou, D.G.Nagle, and G.Shah (2008).
Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.
  J Nat Prod, 71, 396-402.  
18701450 S.Lebreton, S.Paladino, and C.Zurzolo (2008).
Selective roles for cholesterol and actin in compartmentalization of different proteins in the Golgi and plasma membrane of polarized cells.
  J Biol Chem, 283, 29545-29553.  
19008859 S.Mouilleron, S.Guettler, C.A.Langer, R.Treisman, and N.Q.McDonald (2008).
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
  EMBO J, 27, 3198-3208.
PDB codes: 2v51 2v52
18942825 T.Amagata, T.A.Johnson, R.H.Cichewicz, K.Tenney, S.L.Mooberry, J.Media, M.Edelstein, F.A.Valeriote, and P.Crews (2008).
Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.
  J Med Chem, 51, 7234-7242.  
18451854 T.Lämmermann, B.L.Bader, S.J.Monkley, T.Worbs, R.Wedlich-Söldner, K.Hirsch, M.Keller, R.Förster, D.R.Critchley, R.Fässler, and M.Sixt (2008).
Rapid leukocyte migration by integrin-independent flowing and squeezing.
  Nature, 453, 51-55.  
17654480 Y.Chen, P.Pawar, G.Pan, L.Ma, H.Liu, and J.M.McDonald (2008).
Calmodulin binding to the Fas-Mediated death-inducing signaling complex in cholangiocarcinoma cells.
  J Cell Biochem, 103, 788-799.  
18322103 Y.Zhang, J.S.Helm, A.Senatore, J.D.Spafford, L.K.Kaczmarek, and E.A.Jonas (2008).
PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.
  J Neurosci, 28, 2601-2612.  
17716843 A.J.Hordichok, and P.S.Steyger (2007).
Closure of supporting cell scar formations requires dynamic actin mechanisms.
  Hear Res, 232, 1.  
17158457 F.Fazal, M.Minhajuddin, K.M.Bijli, J.L.McGrath, and A.Rahman (2007).
Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells.
  J Biol Chem, 282, 3940-3950.  
17922265 L.Fabian, and A.Forer (2007).
Possible roles of actin and myosin during anaphase chromosome movements in locust spermatocytes.
  Protoplasma, 231, 201-213.  
17118947 T.Chen, N.Teng, X.Wu, Y.Wang, W.Tang, J.Samaj, F.Baluska, and J.Lin (2007).
Disruption of actin filaments by latrunculin B affects cell wall construction in Picea meyeri pollen tube by disturbing vesicle trafficking.
  Plant Cell Physiol, 48, 19-30.  
17284862 T.Usui (2007).
Actin- and microtubule-targeting bioprobes: their binding sites and inhibitory mechanisms.
  Biosci Biotechnol Biochem, 71, 300-308.  
16998842 Y.Azamar, S.Uribe, and A.Mújica (2007).
F-actin involvement in guinea pig sperm motility.
  Mol Reprod Dev, 74, 312-320.  
17167532 B.Sweeting, and J.F.Dawson (2006).
Purification and characterization of a nonpolymerizing long-pitch actin dimer.
  Biochem Cell Biol, 84, 695-702.  
16736254 J.Fiserová, K.Schwarzerová, J.Petrásek, and Z.Opatrný (2006).
ARP2 and ARP3 are localized to sites of actin filament nucleation in tobacco BY-2 cells.
  Protoplasma, 227, 119-128.  
16496225 R.A.Draviam, B.Wang, J.Li, X.Xiao, and S.C.Watkins (2006).
Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells.
  J Muscle Res Cell Motil, 27, 53-67.  
17012745 R.S.Fischer, E.G.Yarmola, K.L.Weber, K.D.Speicher, D.W.Speicher, M.R.Bubb, and V.M.Fowler (2006).
Tropomodulin 3 binds to actin monomers.
  J Biol Chem, 281, 36454-36465.  
17075074 S.Ioannidou, K.Deinhardt, J.Miotla, J.Bradley, E.Cheung, S.Samuelsson, Y.S.Ng, and D.T.Shima (2006).
An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis.
  Proc Natl Acad Sci U S A, 103, 16770-16775.  
16905096 S.M.Margarit, W.Davidson, L.Frego, and C.E.Stebbins (2006).
A steric antagonism of actin polymerization by a salmonella virulence protein.
  Structure, 14, 1219-1229.
PDB codes: 2gwj 2gwk 2gwl 2gwm
16912308 T.Wei, A.Kikuchi, Y.Moriyasu, N.Suzuki, T.Shimizu, K.Hagiwara, H.Chen, M.Takahashi, T.Ichiki-Uehara, and T.Omura (2006).
The spread of Rice dwarf virus among cells of its insect vector exploits virus-induced tubular structures.
  J Virol, 80, 8593-8602.  
16685646 V.Procaccio, G.Salazar, S.Ono, M.L.Styers, M.Gearing, A.Davila, R.Jimenez, J.Juncos, C.A.Gutekunst, G.Meroni, B.Fontanella, E.Sontag, J.M.Sontag, V.Faundez, and B.H.Wainer (2006).
A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
  Am J Hum Genet, 78, 947-960.  
16771841 Y.Chen, T.Chen, S.Shen, M.Zheng, Y.Guo, J.Lin, F.Baluska, and J.Samaj (2006).
Differential display proteomic analysis of Picea meyeri pollen germination and pollen-tube growth after inhibition of actin polymerization by latrunculin B.
  Plant J, 47, 174-195.  
15917332 A.Fürstner, D.Kirk, M.D.Fenster, C.Aïssa, D.De Souza, and O.Müller (2005).
Diverted total synthesis: preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties.
  Proc Natl Acad Sci U S A, 102, 8103-8108.  
15844123 A.Fürstner, and L.Turet (2005).
Concise and practical synthesis of latrunculin a by ring-closing enyne-yne metathesis.
  Angew Chem Int Ed Engl, 44, 3462-3466.  
15800060 A.I.Ivanov, D.Hunt, M.Utech, A.Nusrat, and C.A.Parkos (2005).
Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex.
  Mol Biol Cell, 16, 2636-2650.  
16252969 A.I.Norman, R.Ivkov, J.G.Forbes, and S.C.Greer (2005).
The polymerization of actin: structural changes from small-angle neutron scattering.
  J Chem Phys, 123, 154904.  
16218947 A.K.Dunker, M.S.Cortese, P.Romero, L.M.Iakoucheva, and V.N.Uversky (2005).
Flexible nets. The roles of intrinsic disorder in protein interaction networks.
  FEBS J, 272, 5129-5148.  
15944456 D.E.Levin (2005).
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Microbiol Mol Biol Rev, 69, 262-291.  
16141336 D.S.Kudryashov, M.R.Sawaya, H.Adisetiyo, T.Norcross, G.Hegyi, E.Reisler, and T.O.Yeates (2005).
The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin.
  Proc Natl Acad Sci U S A, 102, 13105-13110.
PDB code: 2a5x
15767368 J.Sasaki, T.Sasaki, M.Yamazaki, K.Matsuoka, C.Taya, H.Shitara, S.Takasuga, M.Nishio, K.Mizuno, T.Wada, H.Miyazaki, H.Watanabe, R.Iizuka, S.Kubo, S.Murata, T.Chiba, T.Maehama, K.Hamada, H.Kishimoto, M.A.Frohman, K.Tanaka, J.M.Penninger, H.Yonekawa, A.Suzuki, and Y.Kanaho (2005).
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
  J Exp Med, 201, 859-870.  
16080205 J.Wang, J.M.Sanger, and J.W.Sanger (2005).
Differential effects of Latrunculin-A on myofibrils in cultures of skeletal muscle cells: insights into mechanisms of myofibrillogenesis.
  Cell Motil Cytoskeleton, 62, 35-47.  
16228898 L.Fabian, and A.Forer (2005).
Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them.
  Protoplasma, 225, 169-184.  
15958494 L.Shen, and J.R.Turner (2005).
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis.
  Mol Biol Cell, 16, 3919-3936.  
16055505 M.Utech, A.I.Ivanov, S.N.Samarin, M.Bruewer, J.R.Turner, R.J.Mrsny, C.A.Parkos, and A.Nusrat (2005).
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane.
  Mol Biol Cell, 16, 5040-5052.  
16322767 P.K.Harris, S.Yeoh, A.R.Dluzewski, R.A.O'Donnell, C.Withers-Martinez, F.Hackett, L.H.Bannister, G.H.Mitchell, and M.J.Blackman (2005).
Molecular identification of a malaria merozoite surface sheddase.
  PLoS Pathog, 1, 241-251.  
15894626 S.Diez, G.Gerisch, K.Anderson, A.Müller-Taubenberger, and T.Bretschneider (2005).
Subsecond reorganization of the actin network in cell motility and chemotaxis.
  Proc Natl Acad Sci U S A, 102, 7601-7606.  
16140751 S.Eash, and W.J.Atwood (2005).
Involvement of cytoskeletal components in BK virus infectious entry.
  J Virol, 79, 11734-11741.  
15657049 Y.Wang, W.Chen, D.M.Simpson, and E.A.Elion (2005).
Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae.
  J Biol Chem, 280, 13084-13096.  
15707892 Z.Gitai, N.A.Dye, A.Reisenauer, M.Wachi, and L.Shapiro (2005).
MreB actin-mediated segregation of a specific region of a bacterial chromosome.
  Cell, 120, 329-341.  
15047870 A.I.Ivanov, I.C.McCall, C.A.Parkos, and A.Nusrat (2004).
Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex.
  Mol Biol Cell, 15, 2639-2651.  
15051729 D.Chodniewicz, A.M.Alteraifi, and D.V.Zhelev (2004).
Experimental evidence for the limiting role of enzymatic reactions in chemoattractant-induced pseudopod extension in human neutrophils.
  J Biol Chem, 279, 24460-24466.  
15347592 G.Gerisch, T.Bretschneider, A.Müller-Taubenberger, E.Simmeth, M.Ecke, S.Diez, and K.Anderson (2004).
Mobile actin clusters and traveling waves in cells recovering from actin depolymerization.
  Biophys J, 87, 3493-3503.  
14742719 J.Banerjee, and P.B.Wedegaertner (2004).
Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.
  Mol Biol Cell, 15, 1760-1775.  
14970238 K.H.Cox, J.J.Tate, and T.G.Cooper (2004).
Actin cytoskeleton is required for nuclear accumulation of Gln3 in response to nitrogen limitation but not rapamycin treatment in Saccharomyces cerevisiae.
  J Biol Chem, 279, 19294-19301.  
15163409 M.Hertzog, C.van Heijenoort, D.Didry, M.Gaudier, J.Coutant, B.Gigant, G.Didelot, T.Préat, M.Knossow, E.Guittet, and M.F.Carlier (2004).
The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly.
  Cell, 117, 611-623.
PDB code: 1sqk
15123724 M.Kanzaki, M.Furukawa, W.Raab, and J.E.Pessin (2004).
Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.
  J Biol Chem, 279, 30622-30633.  
15611334 R.A.Fratti, Y.Jun, A.J.Merz, N.Margolis, and W.Wickner (2004).
Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles.
  J Cell Biol, 167, 1087-1098.  
12566455 A.Pendleton, B.Pope, A.Weeds, and A.Koffer (2003).
Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells.
  J Biol Chem, 278, 14394-14400.  
14576124 C.Oberparleiter, L.Kaiserer, H.Haas, P.Ladurner, M.Andratsch, and F.Marx (2003).
Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli.
  Antimicrob Agents Chemother, 47, 3598-3601.  
14631938 D.Driss-Ecole, A.Lefranc, and G.Perbal (2003).
A polarized cell: the root statocyte.
  Physiol Plant, 118, 305-312.  
14612571 J.Tanaka, Y.Yan, J.Choi, J.Bai, V.A.Klenchin, I.Rayment, and G.Marriott (2003).
Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides.
  Proc Natl Acad Sci U S A, 100, 13851-13856.  
12960380 S.W.Krauss, C.Chen, S.Penman, and R.Heald (2003).
Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro.
  Proc Natl Acad Sci U S A, 100, 10752-10757.  
12631737 T.Pomorski, R.Lombardi, H.Riezman, P.F.Devaux, G.van Meer, and J.C.Holthuis (2003).
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.
  Mol Biol Cell, 14, 1240-1254.  
14578936 V.A.Klenchin, J.S.Allingham, R.King, J.Tanaka, G.Marriott, and I.Rayment (2003).
Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin.
  Nat Struct Biol, 10, 1058-1063.
PDB codes: 1qz5 1qz6
11983702 A.Arai, J.A.Spencer, and E.N.Olson (2002).
STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription.
  J Biol Chem, 277, 24453-24459.  
12388543 D.J.Kusner, J.A.Barton, K.K.Wen, X.Wang, P.A.Rubenstein, and S.S.Iyer (2002).
Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner.
  J Biol Chem, 277, 50683-50692.  
12177043 G.Eitzen, L.Wang, N.Thorngren, and W.Wickner (2002).
Remodeling of organelle-bound actin is required for yeast vacuole fusion.
  J Cell Biol, 158, 669-679.  
12134073 M.Kanzaki, R.T.Watson, J.C.Hou, M.Stamnes, A.R.Saltiel, and J.E.Pessin (2002).
Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.
  Mol Biol Cell, 13, 2334-2346.  
12068306 M.Platani, I.Goldberg, A.I.Lamond, and J.R.Swedlow (2002).
Cajal body dynamics and association with chromatin are ATP-dependent.
  Nat Cell Biol, 4, 502-508.  
11932258 M.R.Bubb, L.Govindasamy, E.G.Yarmola, S.M.Vorobiev, S.C.Almo, T.Somasundaram, M.S.Chapman, M.Agbandje-McKenna, and R.McKenna (2002).
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
  J Biol Chem, 277, 20999-21006.
PDB codes: 1ijj 1lcu
11864995 P.J.Woodring, E.D.Litwack, D.D.O'Leary, G.R.Lucero, J.Y.Wang, and T.Hunter (2002).
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.
  J Cell Biol, 156, 879-892.  
12214236 R.J.Pelham, and F.Chang (2002).
Actin dynamics in the contractile ring during cytokinesis in fission yeast.
  Nature, 419, 82-86.  
12040128 S.Hohmann (2002).
Osmotic stress signaling and osmoadaptation in yeasts.
  Microbiol Mol Biol Rev, 66, 300-372.  
  11739788 I.Rupes, B.A.Webb, A.Mak, and P.G.Young (2001).
G2/M arrest caused by actin disruption is a manifestation of the cell size checkpoint in fission yeast.
  Mol Biol Cell, 12, 3892-3903.  
  11514633 L.Vidali, S.T.McKenna, and P.K.Hepler (2001).
Actin polymerization is essential for pollen tube growth.
  Mol Biol Cell, 12, 2534-2545.  
11533241 S.S.Martin, and P.Leder (2001).
Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2.
  Mol Cell Biol, 21, 6529-6536.  
11137010 K.R.Ayscough (2000).
Endocytosis and the development of cell polarity in yeast require a dynamic F-actin cytoskeleton.
  Curr Biol, 10, 1587-1590.  
10995438 Z.Dai, X.Luo, H.Xie, and H.B.Peng (2000).
The actin-driven movement and formation of acetylcholine receptor clusters.
  J Cell Biol, 150, 1321-1334.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.