UniProt functional annotation for P09211

UniProt code: P09211.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
 
Catalytic activity: RX + glutathione = HX + R-S-glutathione.
Subunit: Homodimer. Interacts with CDK5.
Subcellular location: Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
Similarity: Belongs to the GST superfamily. Pi family.
Similarity: Contains 1 GST C-terminal domain.
Similarity: Contains 1 GST N-terminal domain.

Annotations taken from UniProtKB at the EBI.