Ligand clusters for UniProt code Q9QYJ6

Ligand clusters for Q9QYJ6: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A from Rattus norvegicus

		5 ligand clusters Cluster 1. 12 ligand types 12 ligands Cluster 2. 2 ligand types 10 ligands Cluster 3. 2 ligand types 2 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 2 ligand types 24 ligands
Representative protein: 3lxgA

Structures

PDB		Schematic diagram
3lxgA
2ovvA
2ovyA
3hr1A
3hqzA
		more ...

Cluster 1 contains 12 ligand types

Use checkboxes to select ligands to display in RasMol, Jmol, or download as an SDF file. Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: 227 × 1 6,7-Dimethoxy-4-{8-[(4-Methylpiperazin-1-Yl)sulfonyl]- 3,4-Dihydroisoquinolin-2(1h)-Yl}quinazoline PDB code: 2o8h(A).
		2. Ligand: D4L × 1 2-(3,7-Dimethylquinoxalin-2-Yl)-~{N}-(Oxan-4-Yl)-5- Pyrrolidin-1-Yl-Pyrazolo[1,5-A]pyrimidin-7- Amine PDB code: 6k9u(A).
		3. Ligand: PF4 × 1 4,5-Bis(4-Methoxyphenyl)-2-Thiophen-2-Yl-1h-Imidazole PDB code: 3hqw(A).
		4. Ligand: PF6 × 1 2-({4-[4-(Pyridin-4-Ylmethyl)-1h-Pyrazol-3- Yl]phenoxy}methyl)quinoline PDB code: 3hqy(A).
		5. Ligand: PF8 × 1 2-{[4-(4-Pyridin-4-Yl-1h-Pyrazol-3-Yl) phenoxy]methyl}quinoline PDB code: 3hqz(A).
		6. Ligand: PF9 × 1 2-{[4-(1-Methyl-4-Pyridin-4-Yl-1h-Pyrazol-3-Yl) phenoxy]methyl}quinoline PDB code: 3hr1(A).
		7. Ligand: PFH × 1 6,7-Dimethoxy-4-[(3r)-3-(2-Naphthyloxy)pyrrolidin-1- Yl]quinazoline PDB code: 2ovv(A).
		8. Ligand: PFJ × 1 6,7-Dimethoxy-4-[(3r)-3-(Quinoxalin-2-Yloxy)pyrrolidin- 1-Yl]quinazoline PDB code: 2ovy(A).
		9. Ligand: PFK × 1 6-Methoxy-7-[2-(Quinolin-2-Yl)ethoxy]quinazoline PDB code: 3qpn(A).
		10. Ligand: PFR × 1 7-Methoxy-4-[(3s)-3-Phenylpiperidin-1-Yl]-6-[2- (Pyridin-2-Yl)ethoxy]quinazoline PDB code: 3qpo(A).
		11. Ligand: PFW × 1 7-Methoxy-4-[(3s)-3-Phenylpiperidin-1-Yl]-6-[2- (Quinolin-2-Yl)ethoxy]quinazoline PDB code: 3qpp(A).
		12. Ligand: Z73 × 1 2-Methoxy-6,7-Dimethyl-9-Propylimidazo[1,5-A]pyrido[3, 2-E]pyrazine PDB code: 3lxg(A).

Cluster 2 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: SO4 × 8 Sulfate ion PDB codes: 2ovv(A), 2ovy(A), 3hqy(A), 3qpn(A), 3qpo(A), 3qpp(A).
		2. Ligand: SO4-SO4 × 2 SO4=Sulfate ion. PDB codes: 3hqz(A), 3hr1(A).

Cluster 3 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 3qpp(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 6k9u(A).

Cluster 4 contains 1 ligand type

Selection shortcuts: select all/none invert selection.
Ligand		Description
		1. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 3qpp(A).

Cluster 5 contains 2 ligand types

Selection shortcuts: select all/none invert selection.
Ligand		Description
_Mg		1. Metal: _MG × 12 PDB codes: 2o8h(A), 2ovv(A), 2ovy(A), 3hqw(A), 3hqy(A), 3hqz(A), 3hr1(A), 3lxg(A), 3qpn(A), 3qpo(A), 3qpp(A), 6k9u(A).
_Zn		2. Metal: _ZN × 12 PDB codes: 2o8h(A), 2ovv(A), 2ovy(A), 3hqw(A), 3hqy(A), 3hqz(A), 3hr1(A), 3lxg(A), 3qpn(A), 3qpo(A), 3qpp(A), 6k9u(A).