Ligand clusters for UniProt code Q15661

Ligand clusters for Q15661: Tryptase alpha/beta-1 from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 14 ligand types 23 ligands Cluster 2. 2 ligand types 4 ligands Cluster 3. 1 ligand type 2 ligands Cluster 4. 1 ligand type 2 ligands Cluster 5. 1 ligand type 2 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 2f9nA

Structures

PDB		Schematic diagram
2f9nA
5f03A
2f9pA
6vvuA
4mqaA
		more ...

Cluster 1 contains 14 ligand types

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Ligand		Description
		1. Ligand: SO4 × 5 Sulfate ion PDB codes: 4mpu(A), 4mpv(A), 4mpx(A), 4mqa(A), 6p0p(A).
		2. Ligand: ACE-LEU-LEU-AR7 × 3 ACE=Acetyl group, AR7=Amino{[(4s)-4-Amino-5,5- Dihydroxypentyl]amino}methaniminium. PDB codes: 2f9n(A), 2f9p(A).
		3. Ligand: 0GJ × 2 L-Alpha-Glutamyl-N-{(1s)-4-{[Amino(iminio) methyl]amino}-1-[(1s)-2-Chloro-1- Hydroxyethyl]butyl}glycinamide PDB codes: 5wi6(A), 6vvu(A).
		4. Ligand: 11M × 2 1-(1'-{[3-(Methylsulfanyl)-2-Benzothiophen-1- Yl]carbonyl}spiro[1-Benzofuran-3,4'-Piperidin]-5- Yl) methanamine PDB codes: 2zeb(A),
		5. Ligand: 11N × 2 1-[1'-(3-Phenylacryloyl)spiro[1-Benzofuran-3,4'- Piperidin]-5-Yl]methanamine PDB codes: 2zec(A),
		6. Ligand: 2A4 × 1 (2r,4s)-N,N'-Bis[3-({4-[3-(Aminomethyl) phenyl]piperidin-1-Yl}carbonyl)phenyl]-4-Hydroxy-2-(2- Hydroxypropan-2-Yl)-5,5-Dimethyl-1,3-Dioxolane-2,4- Dicarboxamide PDB code: 4mpv(A).
		7. Ligand: 2AJ × 1 [(1,1,3,3-Tetramethyldisiloxane-1,3-Diyl)di-1- Benzofuran-3,5-Diyl]bis({4-[3- (Aminomethyl) phenyl]piperidin-1-Yl}methanone) PDB code: 4mpw(A).
		8. Ligand: 2AV × 1 [(1,1,3,3-Tetramethyldisiloxane-1,3-Diyl)di-1- Benzothiene-4,2-Diyl]bis({4-[3- (Aminomethyl) phenyl]piperidin-1-Yl}methanone) PDB code: 4mpx(A).
		9. Ligand: 5TA × 1 (5~{s})-5-[[3-(Aminomethyl)phenoxy]methyl]-3-[3-[2-(2- Chloranylpyridin-3-Yl)ethynyl]phenyl]-1,3- Oxazolidin- 2-One PDB code: 5f03(A).
		10. Ligand: ACT × 1 Acetate ion PDB code: 4mpw(A).
		11. Ligand: PGE × 1 Triethylene glycol PDB code: 6p0p(A).
		12. Ligand: X00 × 1 {(1,1,3,3-Tetramethyldisiloxane-1,3-Diyl)bis[5- (Methylsulfanyl)benzene-3,1-Diyl]}bis({4-[3- (Aminomethyl)phenyl]piperidin-1-Yl}methanone) PDB code: 4mqa(A).
		13. Ligand: X2A × 1 (6s,8r)-N,N'-Bis[3-({4-[3-(Aminomethyl) phenyl]piperidin-1-Yl}carbonyl)phenyl]-8-Hydroxy-6-(1- Hydroxycyclobutyl)-5,7-Dioxaspiro[3.4]octane-6,8- Dicarboxamide PDB code: 4mpu(A).
		14. Ligand: Y35 × 1 (3'-{4-[3-(Aminomethyl)phenyl]piperidine-1-Carbonyl}[1, 1'-Biphenyl]-3-Yl){4-[3- (Aminomethyl)phenyl]piperidin- 1-Yl}[3,4-Di(hydroxy-Kappao)phenyl]methanonato(2-) Hydroxyborate(1- ) PDB code: 6p0p(A).

Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: PG4 × 2 Tetraethylene glycol PDB codes: 4mpu(A), 4mqa(A).
		2. Ligand: PGE × 2 Triethylene glycol PDB codes: 4mpw(A), 4mpx(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: MES × 2 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 4mpu(A), 4mpv(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: BU3 × 2 (R,R)-2,3-Butanediol PDB codes: 2f9n(A), 2f9p(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: BU3 × 2 (R,R)-2,3-Butanediol PDB codes: 2f9n(A), 2f9p(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 4mqa(A).
_Cl		2. Metal: _CL × 1 PDB code: 4mpx(A).