Ligand clusters for UniProt code Q13882

Ligand clusters for Q13882: Protein-tyrosine kinase 6 from Homo sapiens

		Top 6 (of 13) ligand clusters Cluster 1. 4 ligand types 4 ligands Cluster 2. 1 ligand type 3 ligands Cluster 3. 1 ligand type 2 ligands Cluster 4. 1 ligand type 3 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 2 ligand types 2 ligands
Representative protein: 5d7vA

Structures

PDB		Schematic diagram
5d7vA
5da3A
5h2uA
6cz4A
6cz3A

Cluster 1 contains 4 ligand types

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Ligand		Description
		1. Ligand: 1N1 × 1 dasatinib N-(2-Chloro-6-Methylphenyl)-2-({6-[4-(2-Hydroxyethyl) piperazin-1-Yl]-2-Methylpyrimidin-4- Yl}amino)-1,3- Thiazole-5-Carboxamide PDB code: 5h2u(A).
		2. Ligand: 58V × 1 (2-Chloro-4-{[6-Cyclopropyl-3-(1h-Pyrazol-4-Yl) imidazo[1,2-A]pyrazin-8-Yl]amino}phenyl)(morpholin- 4- Yl)methanone PDB code: 5da3(A).
		3. Ligand: FKY × 1 2-{[(3r,4s)-3-Fluoro-1-{[4-(Trifluoromethoxy) phenyl]acetyl}piperidin-4-Yl]oxy}-5-(1-Methyl-1h- Imidazol-4-Yl)pyridine-3-Carboxamide PDB code: 6cz4(A).
		4. Ligand: FLJ × 1 (3-Fluoro-4-{[6-Methyl-3-(1h-Pyrazol-4-Yl)imidazo[1,2- A]pyrazin-8-Yl]amino}phenyl)(morpholin-4- Yl)methanone PDB code: 6cz3(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 3 glycerin Glycerol PDB codes: 5d7v(A), 5da3(A), 5h2u(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 5d7v(A), 5h2u(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 3 glycerin Glycerol PDB codes: 5d7v(A), 5da3(A), 5h2u(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: PO4 × 1 Phosphate ion PDB code: 5d7v(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
__K		1. Metal: __K × 1 PDB code: 6cz3(A).
		2. Ligand: ACT × 1 Acetate ion PDB code: 6cz3(A).